A 52-Week Study of Safety and Efficacy of CalciumHydroxylapatite for Rejuvenation of the Aging Hand
January 2011 | Volume 10 | Issue 1 | Original Article | 47 | Copyright © January 2011
Neil S. Sadick MD
Objectives: The investigator sought to determine whether calcium hydroxylapatite (CaHA) could be used as dermal filler for replacement
of volume loss in aging hands.
Methods: The principal investigator injected 1.3 mL of CaHA into the dorsal side of both hands (BH) of 10 female patients (57–68
years of age), for full correction. Investigator, independent evaluator and subjects assessed results at four time points.
Results: Safety. Brief and minor adverse events were reported. Efficacy. Wrinkle severity, improvement and patient satisfaction
were assessed. Wrinkle Severity. Less severity was noted at 12 months than at baseline. Improvement. At nine months 80 percent
of BH were rated as improved or better (IOB) and at 12 months 40 percent of right and 30 percent of left hands as IOB, approximating
findings of the independent evaluator but at some variance from the subjects. Patient Satisfaction. At 12 months, 60 percent of
subjects rated their results as “satisfactory” or better.
Conclusion: In this study, CaHA performed well, with a favorable safety and durability profile. This application expands treatment
options in patients seeking rejuvenation of the aging hand and face.
(J Drugs Dermatol. 2011;10:47-51.)