Urticarial Hypersensitivity Reaction Caused by Temozolomide
September 2010 | Volume 9 | Issue 9 | Case Reports | 1142 | Copyright © September 2010
Salma Pothiawala MD MPH, Mei-Yu Hsu MD, F. Clarissa Yang MD, Santosh Kesari MD PhD, Omar A. Ibrahimi MD PhD
Temozolomide is an oral alkylating agent approved for the treatment of glioblastoma and anaplastic astrocytoma, and is currently
under clinical investigation for the treatment of brain metastases from a variety of cancers. Temozolomide is well tolerated, and the
reported dermatologic side effects of this medication are limited. Here, the authors report the first case of an urticarial hypersensitivity
reaction induced by temozolomide. As this drug will likely be increasingly utilized in the near future, it is important to be aware of
its potential to cause adverse cutaneous manifestations.