Two Cases of Chronic Atopic Dermatitis Treated With Soluble Tumor NecrosisFactor Receptor Therapy
September 2009 | Volume 8 | Issue 9 | Case Reports | 873 | Copyright © September 2009
Peter Rullan MD and Jenny Murase MD
Atopic dermatitis (AD) is a chronic inflammatory disease that is mediated by cytokines. In patients with AD, the use of tumor necrosis
factor (TNF) antagonists has had unpredictable results. Clinically significant improvements in skin symptoms of AD were observed in
two patients with severe, chronic disease who were treated with the soluble TNF receptor etanercept. These observations suggest
that etanercept therapy may be beneficial in patients with AD, particularly chronic variants with lichenification. Studies to identify
features of AD that may predict responsiveness to etanercept therapy in these patients are warranted.