Chemowraps as an Adjuvant to Surgery for Patients With Diffuse Squamous Cell Carcinoma of the Extremities
July 2008 | Volume 7 | Issue 7 | Case Reports | 685 | Copyright © July 2008
Margaret Mann MD, David R. Berk MD, Jeffrey Petersen MD
Methods: A series of 3 representative patients is presented. Before chemowraps were applied, biopsies and clinical lymph node examinations were performed to confirm the diagnosis of SCC. Patients were informed that chemowraps represent an off-label use of 5-FU to reduce actinic keratoses as an adjuvant to definitive surgery for SCCs.
Results: Three patients were referred for diffuse actinic damage and biopsy-proven SCCs on the legs. Patients tolerated chemowraps well (applied for 4-20 weeks) and showed reduction in clinical lesions at 6 weeks to 3 years follow-up.
Conclusions: Chemowraps may be useful in managing patients with diffuse SCCs in fields of severe actinic damage on the extremities. As an adjuvant to surgery, chemowraps may treat surrounding actinic keratoses, help define tumor borders, and minimize the extent of surgery required.