Human Growth Factor and Cytokine Skin Cream for Facial Skin Rejuvenation as Assessed by 3D in Vivo Optical Skin Imaging
October 2007 | Volume 6 | Issue 10 | Original Article | 1018 | Copyright © October 2007
Michael H. Gold MD, Mitchel P. Goldman MD, Julie Biron
Growth factors, in addition to their crucial role in cutaneous wound healing, are also beneficial for skin rejuvenation.
Due to their multifunctional activities such as promoting skin cell proliferation and stimulating collagen formation, growth
factors may participate in skin rejuvenation at various levels. The present placebo-controlled study aimed to further investigate
the antiaging effects of a novel skin cream containing a mixture of human growth factors and cytokines, which
was obtained through a biotechnology process using cultured human fetal fibroblasts. Aside from clinical assessment of
skin wrinkles, the skin surface topography was analyzed by 3D in vivo optical skin imaging using the Phaseshift Rapid in
vivo Measurement of Skin (PRIMOS) device. This device allows fast, contact-free, and direct measurement of the skin
surface topography in vivo at high resolution. This technique is quantitative and more reliable than a visual assessment
of wrinkles using a scoring system, which is subjective and strongly dependent on investigator and assessment conditions.
Using the PRIMOS device, which is also regarded as a more accurate method than the commonly used silicon replica
technique, skin surface roughness was shown to significantly decrease between 10% and 18% depending on the roughness
parameter after 2 months of twice-daily application of the human growth factor and cytokine cream. This was compared
to treatment with the placebo formulation resulting in an approximate 10% decrease of 2 roughness parameters,
whereas the remaining parameters remained unchanged. We found that topical application of growth factors and cytokines
are beneficial in reducing signs of skin aging.