Melanoma in situ with Epidermal Effacement: A Compelling Adjunctive FindingLady C. Dy MD, Larry J. Buckel MD, Robert M. Hurwitz MD
July 2007 | Volume 6 | Issue 7 | Original Article | 708 | Copyright © July 2007
Lady C. Dy MD, Larry J. Buckel MD, Robert M. Hurwitz MD
Since many studies have shown the discordant diagnoses of melanocytic lesions among pathologists despite the existence
of an established histologic criteria, we sought to refine the histologic criteria by finding an additional reliable and reproducible
objective histopathologic feature to aid in the diagnosis of melanoma in situ. We performed a retrospective
analysis of 100 cases histologically diagnosed as melanoma in situ and compared them to a study control group consisting
of junctional benign melanocytic nevi. The epidermis of all the melanocytic lesions was examined for epidermal effacement.
Examination of the epidermis in the study group revealed an absence of epidermal effacement in only 7 (10%)
cases, whereas 93 (93%) cases showed an absence of rete ridges in some foci, making this an overwhelming majority finding
in the cases examined. These results serve as a compelling adjunctive finding that can be used to increase the histologic
diagnostic accuracy of melanoma in situ.