Clearance of Lentigines in Japanese Men with the Long-Pulsed Alexandrite Laser
June 2007 | Volume 6 | Issue 6 | Case Reports | 653 | Copyright © June 2007
Kelley Pagliai Redbord MD, C. William Hanke MD MPH FACP
Background: 5-fluorouracil (5-FU) and imiquimod creams are accepted topical therapies for actinic keratosis (AK). Both
are associated with a prolonged course of treatment with an inflammatory response that may preclude the treatment process.
Objectives: To describe the treatment regimen and the extent of side effects in the use of the combined application of
5-FU and imiquimod creams in patients presenting with AKs and to demonstrate the convenience and ease of the methodology
of this regimen.
Methods: The patients applied 5-FU and imiquimod creams to their lesions daily for one week each month over the course
of 3 months. The patients were seen after the completion of each one-week course to evaluate their progress and side effects.
Results: There were 64 patients in the study, 48 of whom completed the study and demonstrated a clearing of their AKs
by the end of the third course of treatment. All of the patients developed an inflammatory response at the sites of their
AKs as well as at subclinical sites with no apparent AKs. Nearly all of these inflammatory reactions were confined to localized
sites without involvement of the surrounding skin.
Conclusions: Therapy with the combined application of 5-FU and imiquimod creams is a relatively rapid and convenient
form of therapy as compared to the separate use of each medication.