Osteomyelitis Occurring during Infliximab Treatment of Severe Psoriasis
February 2007 | Volume 6 | Issue 2 | Case Reports | 297 | Copyright © February 2007
Jennifer C. Sri BS, Charlotte L. Tsai MD, April Deng MD, Anthony A. Gaspari MD
Tumor necrosis factor alpha (TNF-?) inhibitors, such as infliximab, decrease the body’s inflammatory response and thus
the body’s reaction to infection. Given the immune-mediated processes in psoriasis and psoriatic arthritis, patients with
these disorders may benefit from infliximab therapy but may also suffer from an increased risk of infection. We present the
first case of osteomyelitis in a patient receiving infliximab therapy for severe psoriasis and psoriatic arthritis. Infliximab
and its serious adverse effects are discussed, and other cases of osteomyelitis with infliximab use are also reviewed.