Efficacy of Microdermabrasion Preceding ALA Application in Reducing the Incubation Time of ALA in Laser PDT
February 2007 | Volume 6 | Issue 2 | Original Article | 140 | Copyright © February 2007
Bruce E. Katz MD, Sarah Truong MD, Diane C. Maiwald MD, Kathryn E. Frew MD, Dean George MD
Topical 5-aminolevulinic acid (ALA) and various light sources have been used to treat actinic keratoses and acne. Many of
these regimens have required long incubation times due to the penetration qualities of ALA. This study tested the effectiveness
of ALA in producing erythema when applied for 10 minutes after 2 passes of microdermabrasion versus an incubation
time of one hour without microdermabrasion. The areas were treated with a 595-nm pulsed dye laser at 15 J/cm2 or 22.5 J/cm2.
Photographs were taken at 24 and 48 hours after the treatment. The data indicated consistent superior results with the use of
microdermabrasion prior to the application of ALA for 10 minutes. It appears that incubation of ALA with microdermabrasion
for 10 minutes is as effective as, or more so than, ALA applied alone for one hour in producing erythema.