Comparison of Metformin versus Rosiglitazone in Patients with Acanthosis Nigricans: A Pilot Study
October 2006 | Volume 5 | Issue 9 | Original Article | 884 | Copyright © October 2006
Paula Bellot-Rojas MD, Rosalinda Posadas-Sanchez MSc, Nacu Caracas-Portilla MD, Jose Zamora-Gonzalez MSc, Guillermo Cardoso-Saldaña PhD, Fermin Jurado-Santacruz MD, Carlos Posadas-Romero MD
Background: Acanthosis nigricans (AN) is a skin condition commonly present on the neck of obese subjects. Obesity is
often accompanied by insulin resistance and/or hyperinsulinemia. Metformin and rosiglitazone are 2 pharmacologic agents
useful in conditions characterized by insulin resistance.
Objective: The aim of our study was to compare the efficacy of metformin versus rosiglitazone on AN lesions of the neck as
well as their effects on metabolic and anthropometric variables.
Methods: This 12-week randomized, open-label pilot study involved overweight or obese subjects with AN treat with either
metformin (n=14) or rosiglitazone (n=13).
Results: Only the rosiglitazone group showed a significant reduction in insulin levels. No effect on the severity of AN was
observed, but modest improvements of skin texture occurred in both treatment groups.
Conclusions: Metformin and rosiglitazone were well-tolerated. Although efficacy on skin lesions was very modest, their use
in acanthotic subjects might be useful during longer treatment periods.