Inhibition of Propionibacterium acnes by Bacteriocin-Like Inhibitory Substances (BLIS) Produced by Streptococcus salivarius
October 2006 | Volume 5 | Issue 9 | Original Article | 868 | Copyright © October 2006
Jennifer C. Filip BA, Whitney P. Bowe BS, Joseph M. DiRienzo PhD, Alla Volgina MSc, David J. Margolis MD PhD
We report the in vitro inhibition of Propionibacterium acnes (P. acnes) by a bacteriocin-like inhibitory substance (BLIS-like
substance) produced by Streptococcus salivarius (S. salivarius). Bacteriocins are proteinaceous substances produced by bacteria
that are capable of inhibiting the growth of similar bacterial strains. Unlike classical antibiotics, they have a relatively
narrow spectrum of killing activity, resulting in a reduction in the intensity of selection for resistance. These findings suggest
that BLIS may potentially be used for its anti-P. acnes activity in the treatment of acne.