Severe Refractory Cholinergic Urticaria Treated with Danazol
July 2006 | Volume 5 | Issue 7 | Case Reports | 664 | Copyright © July 2006
MAJ Mark S. La Shell MD, MAJ Ronald W. England MD
Background: Cholinergic urticaria is a form of physical urticaria triggered by a rise in core body temperature. Antihistamines
are the mainstay of treatment; however, adequate symptom control can sometimes be difficult to maintain. Limited data suggest
danazol may be an effective alternative in severe, refractory cases.
Methods and Results: We present a case of a 22-year-old male with severe, refractory cholinergic urticaria. Despite treatment
with high doses of antihistamines, he continued to have symptoms that impaired his ability to function. Treatment
with danazol resulted in a significant improvement in the control of his urticaria.
Discussion: Cholinergic urticaria can sometimes be severe. In cases that fail to respond to traditional forms of treatment,
danazol is a viable alternative for the treatment of cholinergic urticaria. Given the potential adverse effects associated with
its use, danazol should be reserved for more severe and refractory cases.