Puerto Rico Psoriasis Study Group: Efficacy and Safety of Etanercept
November 2005 | Volume 4 | Issue 6 | Original Article | 735 | Copyright © November 2005
José R. González-Chavez MD, Alma C. Berlingeri-Ramos MD, Mary Ann Sánchez Casiano MD
Background:Although major advances in the understanding of its pathogenesis have been achieved, psoriasis remains
an incurable disease. In April 2004, etanercept, an antagonist of TNF-?, was approved by the Food and Drug
Administration for the treatment of chronic, moderate to severe plaque psoriasis in adults. In this study we intend to
document the efficacy and further establish the safety profile of etanercept for the treatment of moderate to severe psoriasis
in our population and compare our data to the Leonardi et al study published in 2003.2
Methods: A total of 26 patients were followed for a period of 24 weeks. Subjects were administered 25 mg of etanercept
subcutaneously twice weekly for 24 weeks. Patients were seen every 4 weeks to measure clinical improvement by
means of the psoriasis area and severity index (PASI) scores. Development of side effects was also assessed.
Results: Ninety-two percent of the patients had an improvement of greater than 50% in their PASI score, with 79%
of these patients with a PASI improvement of 75% or greater. Adverse events were uncommon and none required the
permanent discontinuation of treatment.
Conclusion: Treatment with etanercept was well-tolerated and resulted in significant sustained improvement of psoriasis throughout a period of 24 weeks. Our data stronger correlates with the findings reported by Leonardi et al in 2003.