Isotretinoin in Acne Vulgaris: A Prospective Analysis of 160 Cases from Kuwait
May 2005 | Volume 4 | Issue 3 | Case Reports | 369 | Copyright © May 2005
Nawaf Al-Mutairi MD FRCPC, Y. Manchanda MD DNB, Osama Nour-Eldin MSc, Amani Sultan MB BCH
A total of 160 patients (59 male and 101 female) ages varying from 13 to 28 years (mean age 20 years) with moderate
to severe acne were treated with isotretinoin in the doses ranging from 0.5 mg/kg/day to 1 mg/kg/day. The drug
was given for a period ranging from 6 to 28 weeks. The patients were followed up regularly for a period of 12 months
after stoppage of isotretinoin for any evidence of relapse. In the event of a recurrence greater than mild acne after
8 weeks of stoppage of isotretinoin therapy, the patients were given another course of the drug. Patients were considered
to be non-relapsing if they had no evidence of recurrence after 12 months of follow-up. Twenty seven
patients were excluded from the study. Of the remaining 133 patients (51 male and 82 female) only 117 patients
(36 male and 81 female) could follow up for at least 12 months after stopping therapy. Of the 133 patients, a total
of 127 patients (95.5%) achieved complete or partial clearance. Forty two percent (total 49 patients: 20 male and
29 female) experienced relapse after stopping therapy. Of these, 21 (42.85%) were given a second course of the drug.
None of the patients developed a rise in lipids levels significant enough to warrant stoppage of the drug.