Concurrent Lichen Planopilaris and Female Androgenic Alopecia in Skin of Color: A Case Series

March 2025 | Volume 24 | Issue 3 | 320 | Copyright © March 2025


Published online February 27, 2025

doi:10.36849/JDD.7318

Eliza Balazic MD, Hailey Konisky BS, Eden Axler BS, Kseniya Kobets MD

Division of Dermatology, Department of Medicine, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY

Abstract
Background: Trichoscopy findings can differ in the skin of color requiring a dedicated approach with adequate examination in order to ensure proper diagnosis and treatment. This case series details three cases of concurrent lichen planopilaris (LPP) and female androgenic alopecia (FAGA) in the skin of color.
Methods: Gross examination of all cases revealed mild to moderate hair density thinning of the temporal and frontal scalp. Trichoscopy was done in all three cases before biopsy. The temporal scalp of each patient showed diffuse hair follicle miniaturization with minimal terminal hairs and brown follicular halos, all findings were consistent with FAGA. However, upon inspection of the frontal scalp, each case revealed findings associated with scarring alopecia including scale, erythema, and peripilar casts in addition to the presence of follicle miniaturization.
Results: In the first two cases, two punch biopsies were taken, one from the temporal scalp and one from the frontal scalp. Temporal biopsy revealed FAGA and frontal biopsy revealed LPP arising in a background of AGA. In the third case, only the frontal scalp was biopsied, which showed LPP in a background of FAGA. All three cases received the same treatment regimen; clobetasol 0.05% solution and minoxidil 5% foam/solution topically for treatment of FAGA and monthly intralesional triamcinolone acetonide for treatment of the LPP.
Conclusion: Our report suggests the importance of total scalp dermoscopy and the need for biopsies in areas with varying dermoscopy findings as opposed to areas with the most significant hair loss.

J Drugs Dermatol. 2025;24(3):320-322. doi:10.36849/JDD.7318

INTRODUCTION

Lichen planopilaris (LPP) is a primary scarring alopecia and a follicular version of lichen planus (LP), which can present in association with LP or more often presents alone.1 Androgenetic alopecia is a nonscarring alopecia with a genetic predisposition that leads to pattern baldness.2 In males, it classically begins with bitemporal thinning of the frontal scalp and can involve the vertex while women can present with vertex and frontal scalp involvement.2 Trichoscopy, or scalp dermoscopy, findings can differ in skin of color requiring a dedicated approach to ensure adequate examination to provide proper diagnosis and treatment.3-4 This case series details three cases of concurrent lichen planopilaris (LPP) and female androgenic alopecia (FAGA) in the skin of color.

Case 1
A 52-year-old Black female with a past medical history significant for lupus, depression, and iron deficiency anemia presented to the office with several years of hair loss and recently acquired "bald spots." Her hair loss was reported to be exacerbated by stress. She denied any scalp itching, dryness, pain, or flaking, and denied loss of hair on other parts of her body. In the past, she has had tight braids but removed them because of migraines. Examination revealed moderate thinning at the frontal scalp (Figure 1A) with trichoscopy of the region revealing perifollicular scale, mild erythema, and interruption of honeycomb pattern with the presence of vellus hairs (Figure 1C). Examination of the temporal scalp revealed mild hair density thinning with diffuse hair follicle miniaturization with the presence of pinpoint white dots and brown halos around the hair follicles (Figure 1D). Differential diagnoses included FAGA, cutaneous lupus, diffuse alopecia areata, or traction alopecia exacerbated by telogen effluvium. Due to the differences in trichoscopy findings, two 4 mm