INTRODUCTION
Dynamic lines in the context of aesthetic medicine can be defined as lines of facial expression and are typically treated with chemodenervation from injectable botulinum toxin.1 These lines are created by muscle movement and are thus challenging to improve with topical products.2 Consumer research shows that women are concerned with dynamic lines in the periorbital area, which may be one of the first visible signs of aging. At present, evaluation methods for topical treatments in this area are an unmet need.
The eye area is unique anatomically and socially. The periorbital skin is the thinnest on the entire body, making it the most susceptible to photoaging. However, the thinness is necessary to allow the eye to move, expressing emotion. The fine lines that appear under the eye and in the crow’s feet area in the late twenties and early thirties are a sign of aging. These dynamic lines appear initially only with movement, but later are also present at rest as static lines with advancing age in the later thirties, early forties, and beyond. These dynamic and static periorbital lines worsen with time and are the most sensitive indicator of perceived age.3 Minimizing and assessing the presence of these dynamic and static periorbital lines is an important unmet need in cosmetic science. This research was undertaken to establish the suitability of methodologies to evaluate periorbital lines in motion at maximum smile across a broad age range.
The eye area is unique anatomically and socially. The periorbital skin is the thinnest on the entire body, making it the most susceptible to photoaging. However, the thinness is necessary to allow the eye to move, expressing emotion. The fine lines that appear under the eye and in the crow’s feet area in the late twenties and early thirties are a sign of aging. These dynamic lines appear initially only with movement, but later are also present at rest as static lines with advancing age in the later thirties, early forties, and beyond. These dynamic and static periorbital lines worsen with time and are the most sensitive indicator of perceived age.3 Minimizing and assessing the presence of these dynamic and static periorbital lines is an important unmet need in cosmetic science. This research was undertaken to establish the suitability of methodologies to evaluate periorbital lines in motion at maximum smile across a broad age range.
MATERIALS AND METHODS
Thirty-nine healthy female subjects with mild to moderate photoaging of all Fitzpatrick skin types, ages 28-65 years, were enrolled in this single-site monadic study to evaluate the effect of a targeted topical eye moisturizer on dynamic periorbital eye area lines at maximum smile when applied twice daily for 12 weeks. The population was stratified into two groups: younger female subjects ages 28-40 years, focusing on dynamic lines with minimal static lines (Group D), and older female subjects ages 41-65 years, focusing on dynamic and established static wrinkles (Group SD). Subjects who signed informed consent (Allendale Institutional Review Board (AIRB), Old Lyme, CT) and met all inclusion criteria and none of the exclusion criteria were enrolled at the baseline visit.
