Clinical Assessment of a Novel Jasmonate Cosmeceutical, LR2412-Cx, for the Treatment of Skin Aging

February 2016 | Volume 15 | Issue 2 | Original Article | 209 | Copyright © February 2016


Macrene Alexiades MD PhD

Dermatology and Laser Surgery Center, New York, NY

Abstract
BACKGROUND: The jasmonates are a novel class of plant-derived anti-aging compounds. Among these, LR2412-Cx (tetrahydrojasmonic acid, Visionnaire) has been demonstrated to reduce photoaging and the appearance of wrinkles, as well as to upregulate collagens, hyaluronic acid and fibrillin.
OBJECTIVE: To clinically study the cosmetic effects of a novel jasmonate complex LR2412-Cx in the treatment of visible skin aging.
METHODS: LR2412-Cx was evaluated in a 15-subject open-label prospective clinical trial for the treatment of fine wrinkle appearance, texture, and pores. Subjects were evaluated by an investigator at baseline, day 1, day 3, and week 6 with the Alexiades comprehensive grading scale of skin aging, and introducing a novel pore-grading scale and subject quality of life assessments.
RESULTS: The mean (SEM) at baseline and at week 6 following twice-daily application were: for the appearance of wrinkles 2.91 (0.12) and 2.70 (0.10); for texture 2.91 (0.10) and 2.55 (0.10); and for pores 3.29 (0.08) and 2.46 (0.09), respectively. The differences in all 3 categories at all follow-up intervals were statistically significant (P<.005). The percentage improvement in investigator-assessed grades relative to baseline at day 1, day 3, and week 6 were: 2.3%, 4.9%, and 7.4% for the appearance of wrinkles, 5.7%, 9.4%, and 12.4% for texture, and 14.2%, 21.6% and 25.2% for pores, respectively. No significant untoward effects were reported.
CONCLUSION: Visionnaire LR2412-Cx is a novel jasmonate-containing compound that is safe and effective for the cosmetic treatment of fine wrinkle appearance, texture, and pores of the facial skin.

J Drugs Dermatol. 2016;15(2):209-215.

INTRODUCTION

Undesirable skin changes develop with age and sun exposure. The appearance of fine wrinkles, dyspigmentation, poor texture, and increased pore prominence typically appear as a result of the aging process. Over the past decade, topical anti-aging compounds have increased in number, variety, and efficacy in the delivery of demonstrable clinical results. In the current issue, a novel class of topical plant-derived anti-aging compounds, the jasmonates, is reviewed (Alexiades, current issue). The jasmonates derived their name through the discovery of methyl jasmonate from jasmine oil derived from Jasminum grandiflorum.1 Jasmonic acid is a plant hormone derived from linoleic acid, involved in plant stress regulation, wound repair, and defense.2,3
The jasmonate analog, tetrahydrojasmonic acid (LR2412), has been the most extensively studied for cutaneous application in the treatment of skin aging; and been shown to upregulate hyaluronic acid, laminin-5, collagen IV, and fibrillin.4 In addition, the application of LR2412 resulted in an increase in turnover and thickening of the epidermis.5 The potential for using LR2412 as a clinically applicable topical anti-aging compound is compelling.
In the current study, the results of an open-label prospective clinical trial of a topical anti-aging preparation containing LR2412 jasmonate derivative, called Visionnaire LR2412-Cx, are presented for the treatment of the appearance of fine wrinkles, texture, and pores of facial skin.

METHODS

Subjects

Fifteen healthy volunteers with skin types I to VI who met all inclusion criteria and none of the exclusion criteria were enrolled to the study.

Product Ingredients

LR2412-Cx (Visionnaire, Lancome, L’Oreal USA): Water, cyclohexasiloxane, glycerin, alcohol denat., sodium tetrahydrojasmonate, polysilicone-11, octyldodecanol, HDT/trimethylol hexyllactone crosspolymer, dipropylene glycol, BIS-PEG/PPG-16/16 dimethicone, CI 77891/titanium dioxide, mica, secale cereal extract/rye seed extract, sodium hyaluronate, hydroxyethylcellulose, phenoxyethanol, adenosine, poloxamer 338, ammonium polyacryloyldimethyl taurate, dimethcone, dimethiconol, pentylene glycol, caprylic/capric triglyceride, disodium EDTA, methyldihydrojasmonate, citronellol, inulin lauryl carbamate, parfum/fragrance.

Study Design

Each volunteer filled out baseline and all follow-up subject quality of life (QOL) questionnaires. At baseline and each follow-up
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