INTRODUCTION
Exposure to solar radiation (SR) is associated with a range of adverse effects on the skin, including photocarcinogenesis, sunburn, photoaging, and pigmentation. While the primary focus of SR-induced pathologies has historically centered on the consequences of ultraviolet (UV) radiation, humans are exposed to visible light (VL, 400-700nm), 12 to 14 orders of magnitude greater than UV.1
Wavelengths within the VL spectrum penetrate the full thickness of the epidermis and dermis, extending into the subcutaneous adipose layer;2 whereas UVA penetration does not extend beyond the dermis, and UVB only penetrates the epidermis.3 In addition to exposure from SR, VL is transmitted from flash lamps, computers, televisions, and cell phones.2 Given its pervasive presence and profound penetrative properties, the impact of VL on the skin cannot be disregarded.
Over the past decade, a growing body of literature has strengthened our understanding of the harmful effects of VL on the skin. VL exposure is associated with erythema, post-inflammatory hyperpigmentation (PIH), melasma, and exacerbation of photodermatoses. VL has been shown to induce immediate erythema in skin phototype (SPT) I to III and immediate and prolonged erythema in SPT IV to VI.2 Exposure to VL triggers inflammation and stimulates melanocytes through the generation of reactive oxygen species (ROS), exacerbating hyperpigmentation. In SPT IV to VI, VL has been shown to induce more severe and prolonged pigmentation as compared with UVA1-induced pigmentation,4 underscoring its role in pigmentary disorders in individuals with melanin-rich (MR) skin. VL also plays a role in exacerbating solar urticaria, chronic actinic dermatitis, polymorphous light eruption, and cutaneous porphyrias.2
Accordingly, the importance of sunscreen with VL protection is gaining recognition, especially in the prevention and treatment of pigmentary disorders in individuals with MR skin, who constitute nearly 40% of the United States (U.S.) population.5 Recent studies have demonstrated that additive sunscreen ingredients, including iron oxides, antioxidants, and pigmentary titanium dioxide (TiO2) enhance VL protection and