An Over-the-Counter Healing Ointment: Benefits in Dry Skin and Wound Healing

May 2024 | Volume 23 | Issue 5 | 360 | Copyright © May 2024


Published online April 30, 2024

doi:10.36849/JDD.8224

Aaron S. Farberg MDa, Samantha J. Palomares MS PA-Cb, Thu Q. Nguyen PhDc, Christine Emesiani PharmDc, Matthew Meckfessel PhDc

aBaylor Scott & White Health System, Dallas, TX; University of North Texas Health Science Center, Fort Worth, TX;  Bare Dermatology, Dallas, TX
bBaylor Scott & White Health, Plano, TX
cGalderma Laboratories, L.P., Dallas, TX

Abstract
Background: The use of ointments can be beneficial for dry, chapped, or cracked skin and also for supporting wound healing. We describe the results of 2 studies with an over-the-counter healing ointment (HO) to evaluate the effects on skin hydration and in the setting of wound healing after dermatologic procedures. 
Methods: Study 1 was a single-center, in-use study using HO on qualified areas at least once daily for 4 weeks in subjects with dry, cracked body skin and self-perceived sensitive skin. Study 2 was a multi-center study of wound healing in subjects using HO on a daily basis after having dermatologic surgical procedures. 
Results: In Study 1, there was a significant reduction in skin dryness after 1 and 4 weeks of HO use (P<0.05). Image analysis of the skin revealed a significant increase in skin smoothness after the first application of HO in 100% of subjects (P<0.05). Tolerability and safety were excellent, and HO was well-perceived by subjects throughout the study. In Study 2, HO improved clinical assessments at all time points compared with baseline with a decrease in erythema, edema, scabbing/crusting, and an improvement in overall wound appearance (P<0.05). There was no worsening or significant increase in measures for tolerability parameters at any study visits. Additionally, HO achieved a favorable perception by study subjects. 
Conclusions: HO has a well-established safety profile and has been shown to improve both skin hydration and the overall wound healing process after dermatologic surgical procedures.

J Drugs Dermatol. 2024;23(5):360-365. doi:10.36849/JDD.8224

INTRODUCTION

Dry skin -- leading to a scaly and flaky appearance -- is not only common but is also frequently exacerbated by factors such as frequent cleansing and/or use of harsh cleansers and low relative environmental humidity that can have an additive effect on loss of skin hydration.1 It can be a symptom of skin or systemic diseases but can also occur de novo, particularly in elderly individuals.1 Dry skin often drives pruritus, which can lead to the itch-scratch cycle that can increase infection risk and worsen other skin diseases.1 Both dry skin and pruritus are also associated with a negative impact on patients' quality of life.2 When present in more severe degrees, dry skin can lead to erythema, fissuring, or cracking of the skin.1 Moisturizers and ointments, often over-the-counter (OTC) products, have long been a mainstay for the treatment of dry, cracked skin and have been shown to have therapeutic benefits.3-6 When recommending an OTC product for patients, it is important for clinicians to understand the ability of the product to support skin hydration.

Appropriate post-surgical wound care is critical to rapid skin healing without complications. The foundation of wound management is creating an occlusive, clean, and moist environment to reduce the possibility of infection and support the phases of wound healing.7 To achieve a good condition for wound healing, topical antibiotics, and OTC petrolatum-based ointments are frequently used. Both methods have comparable wound-healing properties, but topical antibiotics can induce drug resistance or cause allergic contact dermatitis.8-10 Thus, ointments are commonly selected as first-line skin protection after dermatologic procedures.

Cetaphil Healing Ointment (HO, Galderma Laboratories, LP, Dallas, TX) is an ideal, multi-functional OTC skin protectant containing petrolatum, shea butter, and vitamin E that can address both dry skin and pruritus. Petrolatum provides occlusion, while shea butter softens, smooths, and hydrates the skin, and vitamin E provides support for moisture levels in the skin. Two studies were conducted with HO, the first to identify the impact on skin dryness and smoothness as well as the subject perception of the product. The second evaluated the efficacy and safety of HO in facilitating wound healing after dermatologic procedures.