A Patient With Neviod Basal Cell Carcinoma Syndrome Treated Successfully With Photodynamic Therapy: Case Report and Review of the Literature

Nevoid basal cell carcinoma syndrome (NBCCS) is a genetic disorder characterized by multiple basal cell carcinomas (BCCs) in addition to skeletal abnormalities and other neoplasms. Difficulty lies in treating the large number of BCCs that develop in these patients. The authors report a case of a patient with NBCCS treated successfully with photodynamic therapy (PDT) using 20% 5-aminolevulinc acid and blue light. The authors also review the literature and summarize past case reports and series using PDT to treat patient with NBCCS. Based on their experience and the reports of others, the authors assert that PDT should become the first-line therapy in the treatment of multiple BCCs in patients with NBCCS.