A Controlled Multi-Center Study Evaluating the Efficacy of VivitÃ© Skin Carein the Treatment of Photoaging of the Face, Eye and Mouth
January 2010 | Volume 9 | Issue 1 | Original Article | 22 | Copyright © January 2010
Mitchel P. Goldman MD and Michael H. Gold MD
Methods: A total of 36 patients between 35 and 65 years of age were randomized on a 3:1 ratio to use either VivitÃ© Skin Care System or Cetaphil cleanser and moisturizer for 60 days. Facial skin was evaluated at baseline, day 30 and day 60. Subjects were required to fill out a self-evaluation of facial skin quality before, during, and after treatment. Investigators evaluated facial wrinkling using a common wrinkling scale as well as a visual evaluation of skin texture in a masked manner.
Results: A similar proportion of patients in each group had a 1-point improvement on the hyperpigmentation scale (42% of VivitÃ© patients, 44% of Cetaphil patients). There were no statistically significant between-group differences in investigator rating of wrinkles. Subjectively, patients preferred VivitÃ© to Cetaphil for noticeable improvement in fine lines or wrinkles (37.6â€“0%, respectively) at the first follow-up. By the final follow-up, more than half the patients in the VivitÃ© group continued to notice an improvement in fine lines or wrinkles, compared with fewer than 25% in the Cetaphil group. More than twice the number of patients in the VivitÃ© group noticed improvement in skin elasticity or tightness compared with those in the Cetaphil group.
Conclusion: Patients reported that the VivitÃ© skin care system improved the appearance of wrinkling and improved skin texture associated with moderate photoaging of the face, eye and mouth areas. VivitÃ© had a higher patient preference rating than a commonly used moisturizing regimen. There were no differences noted in the physician evaluations.