INTRODUCTIONPsoriatic disease is a common chronic immune-mediated systemic inflammatory disease, most often presenting as chronic plaque psoriasis with erythematous, scaly lesions that cause pain, pruritus, and cosmetic burden.1 The pathophysiology…
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INTRODUCTIONPsoriasis is a chronic immune‑mediated inflammatory skin disease that is strongly associated with metabolic dysregulation and excess adiposity.1 Adipose tissue dysfunction contributes to systemic inflammation, promoting Th17/IL‑17 pathways that drive…
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INTRODUCTIONWith an estimated global prevalence of >9% across all ages, acne vulgaris is one of the most common skin disorders.1 However, acne prevalence among adults may be increasing, particularly for…
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INTRODUCTIONMolluscum contagiosum (MC), caused by the molluscum contagiosum virus (MCV), is a cutaneous infection that commonly affects children.1 Molluscum can significantly impair quality of life, contributing to social stigma, discomfort,…
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INTRODUCTIONPsoriasis is a chronic inflammatory condition affecting the skin.1,2 Pathophysiology involves Th1- and Th17-driven inflammation with consequently increased levels of TNF-α, IL-17, and IL-23.3 Patients with psoriasis are at increased…
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INTRODUCTIONRosacea is a chronic inflammatory facial skin condition characterized by episodic or persistent erythema, edema, telangiectasias, and/or inflammatory papules and pustules.1 The global prevalence of rosacea is approximately 5.46%, with…
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INTRODUCTIONGeneralized pustular psoriasis (GPP) is a rare, chronic, severe autoinflammatory dermatosis distinguished by abrupt flares of sterile pustulation, systemic inflammation, and substantial morbidity and mortality.1-4 Once viewed as a variant…
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In this issue:Generalized Pustular Psoriasis: A Contemporary Review of Diagnosis, Pathophysiology, and IL-36 Pathway–Directed ManagementGeneralized pustular psoriasis (GPP) is a rare, chronic, severe autoinflammatory dermatosis distinguished by abrupt flares of…
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INTRODUCTIONJanus kinase (JAK) inhibitors are increasingly prescribed for inflammatory and autoimmune diseases, including atopic dermatitis (AD), alopecia areata (AA), psoriasis/psoriatic arthritis (PsO/PsA), and inflammatory bowel disease (IBD).1-2 Their use has…
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INTRODUCTIONEczema is a prevalent, chronic skin condition with the highest burden among skin disorders globally, affecting approximately 20% of children and up to 10% of adults.1,2 The condition is characterized…
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INTRODUCTIONPatients are increasingly turning to social media for disease/treatment advice and support.1 This has varying benefits2 but involves the risk of inaccurate information.3,4 Reddit, a news/social content discussion platform site…
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INTRODUCTIONTirzepatide is a dual glucagon-like pedtide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) agonist and is primarily used to improve glycemic control along with weight reduction. It has also demonstrated anti-inflammatory…
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