INTRODUCTION
As skin ages, problems emerge, including fine lines, deep wrinkles, sagging, dryness, and rough or uneven texture. It is further known that sun exposure, pollution, and lifestyle choices (such as smoking) exacerbate skin stress, causing collagen degradation, chronic inflammation, and other manifestations that can contribute to visual signs of aging. Meanwhile, the body’s intrinsic restorative mechanisms slow as we age, leading to faster collagen and elastin denaturation, increased inflammation, and loss of skin firmness and density.1Growth factors can regulate several important processes to treat and prevent the signs of skin aging. Key examples include cell replication, collagen production, and the reduction of inflammation.2,3 In clinical studies, applying growth factors topically has been shown to strengthen the skin’s ECM, signs of photoaging by stimulating collagen and elastin, and trigger the skin’s innate ability to heal.3-7Advances in genomics and molecular biology have unveiled multiple pathways and methods of intervention in which aged and damaged skin health can be restored. Growth factors of multiple origins have been clinically proven to augment many of the biological pathways that naturally occur in the skin to restore aged and damaged skin. The use of plant-derived or enzymatically derived stem cells can offer preferred options, as they can be more sustainably cultivated versus human or animal-derived stem cells and are not inherently susceptible to the presence of disease-causing contaminants.Dermal cells are primarily responsible for the production of the structural framework within skin, which is primarily com
