Clinical Evidence of Dermal and Epidermal Restructuring from a Biologically Active Growth Factor Serum for Skin Rejuvenation

March 2019 | Volume 18 | Issue 3 | Original Article | 290 | Copyright © March 2019


Frank Barone MD FACS,a Sameer Bashey MD FAAD,b and Frederick W. Woodin Jr. BSc

aEvolv Plastic Surgery and Medical Aesthetics, Toledo, OH bZO Skin Centre, Beverly Hills, CA cZO Skin Health, Inc., Irvine, CA

provement of one deeper wrinkle can create multiple finer lines, a single elongated line, or multiple fine lines that are located so close together that the imaging algorithm reads them as the width of one wrinkle rather than of two wrinkles.Improvements in total wrinkle count lost statistical significance at weeks 4 and 12. As with wrinkle width and length, treatment potentially could alter one deep line into multiple finer lines, thus increasing total line count.Emerging line counts worsened throughout the study period, from 19.61 ± 9.76 at baseline to 24.54 ± 10.19 at week 12. The increase in emerging line counts may be linked to the reduction in fine line count, as analysis software may have interpreted smaller, less severe post-treatment lines as new, emerging lines.

CONCLUSIONS

Based on expert visual grading, corneometer and cutometer evaluations, and 2D and 3D image analyses, the study product resulted in significant improvements in facial skin appearance, firmness, elasticity, and hydration. Elements that improved most dramatically in investigators’ assessments included radiance, firmness, tactile elasticity, textural smoothness, overall appearance, and crow’s feet. Ultrasound imaging showed increased dermal thickness as early as week 4, which continued through week 12. Additionally, subject questionnaires reflected a significantly positive perception of the product’s effects, and high product tolerance through 12 weeks’ use. Thus, the study product demonstrated the ability to provide a safe and effective solution to address several key concerns in facial skin aging.

DISCLOSURES

Dr. Frank Barone and Dr. Sameer Bashey are actively engaged in retail sales of ZO Skin Health products.Frederick Woodin Jr. is an employee of ZO Skin Health, Inc.

ACKNOWLEDGMENTS

Denver, Colorado-based medical writer John Jesitus assisted in the preparation of the study manuscript. ZO Skin Health, Inc., was the sponsor of this research.

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AUTHOR CORRESPONDENCE

7. Hussain M, Phelps R, Goldberg DJ. Clinical, histologic, and ultrastructural changes after use of human growth factor and cytokine skin cream for the treatment of skin rejuvenation. J Cosmet Laser Ther. 2008;10(2):104-9.8. Lee HS, Kim MR, Park Y, et al. Fermenting red ginseng enhances its safety and efficacy as a novel skin care anti-aging ingredient: in vitro and animal study. J Med Food. 2012;15(11):1015-1023.9. Induchem. NovHyal Biotech G Molecular Pro-filler. http://truactivs.com/wp-content/uploads/2015/07/NOVHYAL-BIOTECH-G.pdf. Published 2012. Accessed October 25, 2018.10. Joseph B, Raj SJ. Therapeutic applications and properties of silk proteins from Bombyx mori. Front Life Sci. 2012;6:55-60.11. Jagtapb SG, Khyade VB. Effect of silk sericin from the cocoons of silk worm, Antheraea mylitta (L) and Bombyx mori (L) on hydrogen peroxide induced oxidative stress in feline fibroblasts. Am J Engineering Res. 2016;5(11):180- 186.12. Hosoe M, Yoshida N, Hashiyada Y, et al. Sericin accelerates the production of hyaluronan and decreases the incidence of polyspermy fertilization in bovine oocytes during in vitro maturation. J Reprod Dev. 2014;60:268-273.13. Debono J, Xie B, Violette A, et al. Viper venom Botox: the molecular origin and evolution of the Waglerin peptides used in anti-wrinkle skin cream. J Mol Evol. 2017;84(1):8-11.14. Data on file (DC Provesselin). Resources of Nature Inc.15. Resources of Nature Inc. DC Provesselin product datasheet. http://resourcesofnature.com/images/DC_Provesselin.pdf. Revised July 5, 2013. Accessed November 5, 2018.16. Resources of Nature Inc. Distinctive Phytostem Buddleja product datasheet. Revised October 18, 2010. Accessed November 5, 2018.17. BotanicalsPlus. Naturally Derived Active Ingredients. https://botanicalsplus. com/Brochures/BP_Natural_Actives.pdf. Accessed November 5, 2018.