A Fern with Far-Reaching Potential: The Role of Polypodium Leucotomos Extract in Dermatology
From photoaging to pigmentary disorders, Polypodium leucotomos extract (PLE)—a botanical with notable photoprotective and anti-inflammatory properties—has emerged as a promising adjunct in dermatologic care. While often spotlighted for its role in sun protection, could its applications go even further?
This systematic review pulls together the current evidence on PLE use across a range of conditions, from vitiligo and melasma to actinic keratosis and photodermatoses. With encouraging safety data and growing interest, PLE may be poised to become more than just a supplement.
J Drugs Dermatol. 2025;24(4):346–351. doi:10.36849/JDD.8410R1
