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Oral Collagen Supplementation: A Systematic Review of Dermatological Applications

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Nutrition is thought to play an important role in skin homeostasis. The use of nutraceuticals or “functional foods” in skincare along with technological innovations within the food industry has been rising.

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Nutrition is thought to play an important role in skin homeostasis. The use of nutraceuticals or “functional foods” in skincare along with technological innovations within the food industry has been rising.

Franchesca D. Choi BS RPh, Calvin T. Sung BS, Margit L.W. Juhasz MD, Natasha Atanaskova Mesinkovska MD PhD

 

 In 2016, the collagen market was valued at an estimated 3.71 billion USD and is projected to reach 6.63 billion USD by 2025. Collagen supplements, originating from various sources (eg, porcine, bovine, marine) and available in numerous formulations (eg, protein, gelatin, hydrolysate, peptides), are marketed as improving skin integrity and modulating skin aging. However, even with this increase in patient interest and market share, the use of collagen supplementation in dermatology remains controversial due to the lack of regulation on quality and quantity of ingredients in over-the-counter collagen supplements, as well as minimal peer-reviewed literature on the subject.

Fortunately, there are increasing numbers of clinical studies regarding potential effects of collagen-based dietary supplements on skin. Collagen is the most abundant component of the extracellular matrix constituting 75% of skin’s dry weight.5 Qualitative and quantitative decline in collagen is associated with cutaneous aging.6 Collagen protein is a right-handed triple helix of parallel polypeptides where every third amino acid residue is glycine (Gly) resulting in X-Y-Gly triplets, where X andY are frequently proline (Pro) and 4-hydroxyproline (Hyp; an amino acid sub- unit unique to collagen), respectively,7 making Pro-Hyp-Gly the most common amino acid triplet unit found in collagen

Native, animal collagen can be extracted from connective tissue in various forms.10 When denatured by heat, collagen forms gelatin, which has been used for centuries as a food source and traditional medicine in Europe and China.

Further enzymatic hydrolysis of gelatin produces collagen hydrolysates (CH) composed of peptides of varying lengths. CH has a lower molecular weight than gelatin, higher water-solubility, and no gelation properties at ambient temperatures, allowing CH to be conveniently formulated into liquid drinks and jelly sticks for oral consumption. In the past decade, CHs have gained popularity as a nutraceutical supplement.

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Colloidal Oatmeal Part I: Clinical Efficacy in the Treatment of Atopic Dermatitis

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Colloidal oatmeal has a long-standing history in the treatment of dermatologic disease. It is composed of various phytochemicals, which contribute to its wide-ranging function and clinical use. It has various…

Oral Collagen Supplementation: A Systematic Review of Dermatological Applications

| Featured Articles | No Comments
Nutrition is thought to play an important role in skin homeostasis. The use of nutraceuticals or “functional foods” in skincare along with technological innovations within the food industry has been…

Revisiting Handwashing – As It Is Absolutely Essential

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As the coronavirus pandemic continues into the second half of 2020, states across the US remain steadfast in their search to determine the safest methods of returning to normalcy. Without…

Oral Collagen Supplementation: A Systematic Review of Dermatological Applications

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Featured Article

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800 patients who took up to 10 grams of collagen per day, experienced improvement in skin elasticity, moisture retention, and increased density of collagen fibers in the skin.

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Improvements in skin health is a well-researched benefit of taking collagen – in fact, according to a January 2019 Journal of Drugs in Dermatology study, (recently featured in an Every Day Health article, ” 8 Potential Benefits of Collagen – and 1 Thing it Can’t Do”), 800 patients who took up to 10 grams of collagen per day, experienced improvement in skin elasticity, moisture retention, and increased density of collagen fibers in the skin.

Franchesca D. Choi BS RPh, Calvin T. Sung BS, Margit L.W. Juhasz MD, Natasha Atanaskova Mesinkovska MD PhD

Nutrition is thought to play an important role in skin homeostasis. The use of nutraceuticals or “functional foods” in skincare along with technological innovations within the food industry has been rising.

In 2016, the collagen market was valued at an estimated 3.71 billion USD and is projected to reach 6.63 billion USD by 2025. Collagen supplements, originating from various sources (eg, porcine, bovine, marine) and available in numerous formulations (eg, protein, gelatin, hydrolysate, peptides), are marketed as improving skin integrity and modulating skin aging.

However, even with this increase in patient interest and market share, the use of collagen supplementation in dermatology remains controversial due to the lack of regulation on quality and quantity of ingredients in over-the-counter collagen supplements, as well as minimal peer-reviewed literature on the subject. Fortunately, there are increasing numbers of clinical studies regarding potential effects of collagen-based dietary supplements on skin.

Read Full Article Now
Article Cited in this Post

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Colloidal Oatmeal Part I: Clinical Efficacy in the Treatment of Atopic Dermatitis

| Atopic Dermatitis, Featured Articles, The Latest | No Comments
Colloidal oatmeal has a long-standing history in the treatment of dermatologic disease. It is composed of various phytochemicals, which contribute to its wide-ranging function and clinical use. It has various…

Oral Collagen Supplementation: A Systematic Review of Dermatological Applications

| Featured Articles | No Comments
Nutrition is thought to play an important role in skin homeostasis. The use of nutraceuticals or “functional foods” in skincare along with technological innovations within the food industry has been…

Revisiting Handwashing – As It Is Absolutely Essential

| Featured Articles, Global Health, The Latest | No Comments
As the coronavirus pandemic continues into the second half of 2020, states across the US remain steadfast in their search to determine the safest methods of returning to normalcy. Without…