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Oral Collagen Supplementation: A Systematic Review of Dermatological Applications

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Nutrition is thought to play an important role in skin homeostasis. The use of nutraceuticals or “functional foods” in skincare along with technological innovations within the food industry has been rising.

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Nutrition is thought to play an important role in skin homeostasis. The use of nutraceuticals or “functional foods” in skincare along with technological innovations within the food industry has been rising.

Franchesca D. Choi BS RPh, Calvin T. Sung BS, Margit L.W. Juhasz MD, Natasha Atanaskova Mesinkovska MD PhD

 

 In 2016, the collagen market was valued at an estimated 3.71 billion USD and is projected to reach 6.63 billion USD by 2025. Collagen supplements, originating from various sources (eg, porcine, bovine, marine) and available in numerous formulations (eg, protein, gelatin, hydrolysate, peptides), are marketed as improving skin integrity and modulating skin aging. However, even with this increase in patient interest and market share, the use of collagen supplementation in dermatology remains controversial due to the lack of regulation on quality and quantity of ingredients in over-the-counter collagen supplements, as well as minimal peer-reviewed literature on the subject.

Fortunately, there are increasing numbers of clinical studies regarding potential effects of collagen-based dietary supplements on skin. Collagen is the most abundant component of the extracellular matrix constituting 75% of skin’s dry weight.5 Qualitative and quantitative decline in collagen is associated with cutaneous aging.6 Collagen protein is a right-handed triple helix of parallel polypeptides where every third amino acid residue is glycine (Gly) resulting in X-Y-Gly triplets, where X andY are frequently proline (Pro) and 4-hydroxyproline (Hyp; an amino acid sub- unit unique to collagen), respectively,7 making Pro-Hyp-Gly the most common amino acid triplet unit found in collagen

Native, animal collagen can be extracted from connective tissue in various forms.10 When denatured by heat, collagen forms gelatin, which has been used for centuries as a food source and traditional medicine in Europe and China.

Further enzymatic hydrolysis of gelatin produces collagen hydrolysates (CH) composed of peptides of varying lengths. CH has a lower molecular weight than gelatin, higher water-solubility, and no gelation properties at ambient temperatures, allowing CH to be conveniently formulated into liquid drinks and jelly sticks for oral consumption. In the past decade, CHs have gained popularity as a nutraceutical supplement.

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Colloidal Oatmeal Part I: Clinical Efficacy in the Treatment of Atopic Dermatitis

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Colloidal oatmeal has a long-standing history in the treatment of dermatologic disease. It is composed of various phytochemicals, which contribute to its wide-ranging function and clinical use. It has various…

Oral Collagen Supplementation: A Systematic Review of Dermatological Applications

| Featured Articles | No Comments
Nutrition is thought to play an important role in skin homeostasis. The use of nutraceuticals or “functional foods” in skincare along with technological innovations within the food industry has been…

Revisiting Handwashing – As It Is Absolutely Essential

| Featured Articles, Global Health, The Latest | No Comments
As the coronavirus pandemic continues into the second half of 2020, states across the US remain steadfast in their search to determine the safest methods of returning to normalcy. Without…

View the Latest Discoveries in Atopic Dermatitis, Anti-Aging, and Medical Dermatology

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Dermatology News

JDD Highlights

The October issue of the Journal of Drugs in Dermatology is available now. This month, we focus on atopic dermatitis with special features on Public Health, Anti-aging, Aesthetic, and Medical Dermatology.

Read the October JDD Now

Atopic Dermatitis, Public Health, Anti-Aging, and Medical Dermatology

The October issue of the Journal of Drugs in Dermatology is available now. This month, we focus on atopic dermatitis, with special features on Public Health, Anti-aging, Aesthetic, and Medical Dermatology.

Article Highlights

 

Editor's Picks

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Colloidal Oatmeal Part I: Clinical Efficacy in the Treatment of Atopic Dermatitis

| Atopic Dermatitis, Featured Articles, The Latest | No Comments
Colloidal oatmeal has a long-standing history in the treatment of dermatologic disease. It is composed of various phytochemicals, which contribute to its wide-ranging function and clinical use. It has various…

Oral Collagen Supplementation: A Systematic Review of Dermatological Applications

| Featured Articles | No Comments
Nutrition is thought to play an important role in skin homeostasis. The use of nutraceuticals or “functional foods” in skincare along with technological innovations within the food industry has been…

Treating the AD Patient During COVID-19

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iTunes Google Play Stitcher TuneIn Dr. Peter Lio and Dr. Adam Friedman   Atopic dermatitis is a relentless, recurring, unreasonable, often recalcitrant inflammatory skin disease that impacts millions of children…

What are the Skincare Benefits of Niacinamide?

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A 2016 study from Journal of Drugs in Dermatology suggests that a topical cream containing retinol 0.5% in combination with niacinamide, resveratrol, and hexylresorcinol is efficacious and tolerable for skin brightening/anti-aging when used with a complementary skin care regimen including SPF 30 sun protection.

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A 2016 study from Journal of Drugs in Dermatology (“Efficacy and Tolerability of a Skin Brightening/Anti-Aging Cosmeceutical Containing Retinol 0.5%, Niacinamide, Hexylresorcinol, and Resveratrol“), which was recently cited in an article on Prevention.com, suggests that a topical cream containing retinol 0.5% in combination with niacinamide, resveratrol, and hexylresorcinol is efficacious and tolerable for skin brightening/anti-aging when used with a complementary skin care regimen including SPF 30 sun protection. 

Patricia Farris MD, Joshua Zeichner MD, and Diane Berson MD

 

Consumers are increasingly interested in over-the-counter skin care products that can improve the appearance of photodamaged and aging skin. This 10-week, open-label, single- center study enrolled 25 subjects with mild to moderate hyperpigmentation and other clinical stigmata of cutaneous aging including fine lines, sallowness, lack of clarity, and wrinkling. Their mean age was 53.4±7.7 years. The test product contained retinol 0.5% in combination with niacinamide 4.4%, resveratrol 1%, and hexylresorcinol 1.1% in a moisturizing base. Subjects were provided a skin care regimen including a cleanser, hydrating serum, moisturizer, and an SPF 30 sunscreen for daily use. The test product was applied only at night.

The use of this skin brightening/anti-aging cosmeceutical was found to provide statistically significant improvements in all efficacy endpoints by study end. Fine lines, radiance, and smoothness were significantly improved as early as week 2 (P<.001). By week 4, hyperpigmentation, overall skin clarity, evenness of skin tone, and wrinkles showed statistically significant improvement compared to baseline. Mild retinoid dermatitis including flaking and redness occurred early in the study as reflected by tolerability scores. By week 10, subjects reported no stinging, itching, dryness, or tingling.

The results of this open-label clinical study suggest that a topical cream containing retinol 0.5% in combination with niacinamide, resveratrol, and hexylresorcinol is efficacious and tolerable for skin brightening/anti-aging when used with a complementary skin care regimen including SPF 30 sun protection.

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Colloidal Oatmeal Part I: Clinical Efficacy in the Treatment of Atopic Dermatitis

| Atopic Dermatitis, Featured Articles, The Latest | No Comments
Colloidal oatmeal has a long-standing history in the treatment of dermatologic disease. It is composed of various phytochemicals, which contribute to its wide-ranging function and clinical use. It has various…

Oral Collagen Supplementation: A Systematic Review of Dermatological Applications

| Featured Articles | No Comments
Nutrition is thought to play an important role in skin homeostasis. The use of nutraceuticals or “functional foods” in skincare along with technological innovations within the food industry has been…

Revisiting Handwashing – As It Is Absolutely Essential

| Featured Articles, Global Health, The Latest | No Comments
As the coronavirus pandemic continues into the second half of 2020, states across the US remain steadfast in their search to determine the safest methods of returning to normalcy. Without…

Biological Effects of Hyaluronic Acid-Based Dermal Fillers and Laser Therapy on Human Skin Models

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This study investigates the molecular effects of different stabilized HA and poly-l-lactic acid (PLLA)-based fillers with and without subsequent additional fractional laser co-treatment.

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This study investigates the molecular effects of different stabilized HA and poly-l-lactic acid (PLLA)-based fillers with and without subsequent additional fractional laser co-treatment.

Laura Huth PhD, Yvonne Marquardt, Ruth Heise PhD, Katharina Fietkau, Jens Malte Baron MD, Sebastian Huth PhD

 

Injection of hyaluronic acid (HA) dermal fillers is one of the most frequently performed aesthetic procedures. HA fillers exist in many different formulations differing in HA concentration, particle size and cross-linking density.

While HA fillers with high-density and large particles are recommended for deep dermal injections, fillers with low-density and small particles are more commonly used for fine lines.

The direct biological effects of dermal fillers monotherapy and combination therapy with ablative fractional CO2- or Er:YAG laser irradiation on human skin cells are not completely understood. Organotypic three-dimensional (3D) skin equivalents have been established for standardized studies of the human skin.

The aim of the present study was to investigate the molecular effects of different stabilized HA and poly-l-lactic acid (PLLA)-based fillers with and without subsequent additional fractional laser co-treatment.

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Colloidal Oatmeal Part I: Clinical Efficacy in the Treatment of Atopic Dermatitis

| Atopic Dermatitis, Featured Articles, The Latest | No Comments
Colloidal oatmeal has a long-standing history in the treatment of dermatologic disease. It is composed of various phytochemicals, which contribute to its wide-ranging function and clinical use. It has various…

Oral Collagen Supplementation: A Systematic Review of Dermatological Applications

| Featured Articles | No Comments
Nutrition is thought to play an important role in skin homeostasis. The use of nutraceuticals or “functional foods” in skincare along with technological innovations within the food industry has been…

Revisiting Handwashing – As It Is Absolutely Essential

| Featured Articles, Global Health, The Latest | No Comments
As the coronavirus pandemic continues into the second half of 2020, states across the US remain steadfast in their search to determine the safest methods of returning to normalcy. Without…

Oral Collagen Supplementation: A Systematic Review of Dermatological Applications

By Aesthetics, Featured Articles, New Articles No Comments

Featured Article

Featured Article

800 patients who took up to 10 grams of collagen per day, experienced improvement in skin elasticity, moisture retention, and increased density of collagen fibers in the skin.

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Improvements in skin health is a well-researched benefit of taking collagen – in fact, according to a January 2019 Journal of Drugs in Dermatology study, (recently featured in an Every Day Health article, ” 8 Potential Benefits of Collagen – and 1 Thing it Can’t Do”), 800 patients who took up to 10 grams of collagen per day, experienced improvement in skin elasticity, moisture retention, and increased density of collagen fibers in the skin.

Franchesca D. Choi BS RPh, Calvin T. Sung BS, Margit L.W. Juhasz MD, Natasha Atanaskova Mesinkovska MD PhD

Nutrition is thought to play an important role in skin homeostasis. The use of nutraceuticals or “functional foods” in skincare along with technological innovations within the food industry has been rising.

In 2016, the collagen market was valued at an estimated 3.71 billion USD and is projected to reach 6.63 billion USD by 2025. Collagen supplements, originating from various sources (eg, porcine, bovine, marine) and available in numerous formulations (eg, protein, gelatin, hydrolysate, peptides), are marketed as improving skin integrity and modulating skin aging.

However, even with this increase in patient interest and market share, the use of collagen supplementation in dermatology remains controversial due to the lack of regulation on quality and quantity of ingredients in over-the-counter collagen supplements, as well as minimal peer-reviewed literature on the subject. Fortunately, there are increasing numbers of clinical studies regarding potential effects of collagen-based dietary supplements on skin.

Read Full Article Now
Article Cited in this Post

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Colloidal Oatmeal Part I: Clinical Efficacy in the Treatment of Atopic Dermatitis

| Atopic Dermatitis, Featured Articles, The Latest | No Comments
Colloidal oatmeal has a long-standing history in the treatment of dermatologic disease. It is composed of various phytochemicals, which contribute to its wide-ranging function and clinical use. It has various…

Oral Collagen Supplementation: A Systematic Review of Dermatological Applications

| Featured Articles | No Comments
Nutrition is thought to play an important role in skin homeostasis. The use of nutraceuticals or “functional foods” in skincare along with technological innovations within the food industry has been…

Revisiting Handwashing – As It Is Absolutely Essential

| Featured Articles, Global Health, The Latest | No Comments
As the coronavirus pandemic continues into the second half of 2020, states across the US remain steadfast in their search to determine the safest methods of returning to normalcy. Without…

View the Latest Discoveries in Aesthetics, Anti-Aging, and Medical Dermatology

By Featured Articles, JDD Highlights No Comments

Dermatology News

JDD Highlights

September JDD

The September issue of the Journal of Drugs in Dermatology is available now. This month, we focus on aesthetic treatments, with special features on Public Health, Anti-aging, Aesthetic, and Medical Dermatology.

Read the September JDD Now

Aesthetics, Public Health, Anti-Aging, and Medical Dermatology

The September issue of the Journal of Drugs in Dermatology is available now. This month, we focus on aesthetic treatments, with special features on Public Health, Anti-aging, Aesthetic, and Medical Dermatology.

Article Highlights

 

Editor's Picks

 

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Colloidal Oatmeal Part I: Clinical Efficacy in the Treatment of Atopic Dermatitis

| Atopic Dermatitis, Featured Articles, The Latest | No Comments
Colloidal oatmeal has a long-standing history in the treatment of dermatologic disease. It is composed of various phytochemicals, which contribute to its wide-ranging function and clinical use. It has various…

Oral Collagen Supplementation: A Systematic Review of Dermatological Applications

| Featured Articles | No Comments
Nutrition is thought to play an important role in skin homeostasis. The use of nutraceuticals or “functional foods” in skincare along with technological innovations within the food industry has been…

Treating the AD Patient During COVID-19

| Podcast Highlights | No Comments
iTunes Google Play Stitcher TuneIn Dr. Peter Lio and Dr. Adam Friedman   Atopic dermatitis is a relentless, recurring, unreasonable, often recalcitrant inflammatory skin disease that impacts millions of children…

The Latest Research & Discoveries in Psoriasis, Anti-Aging, Aesthetics, and Medical Dermatology

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Dermatology News

JDD Highlights

The August issue of the Journal of Drugs in Dermatology is available now. This month, we focus on Psoriasis, with special features on Public Health, Anti-aging, Aesthetic, and Medical Dermatology.

Read the JDD Now

Psoriasis, Public Health, Anti-Aging, Aesthetic, and Medical Dermatology

The August issue of the Journal of Drugs in Dermatology is available now. This month, we focus on  psoriasis with special features on Public Health, Anti-aging, Aesthetic, and Medical Dermatology.

Article Highlights

Editor's Picks

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Atopic DermatitisFeatured ArticlesThe Latest
November 16, 2020

Colloidal Oatmeal Part I: Clinical Efficacy in the Treatment of Atopic Dermatitis

Colloidal oatmeal has a long-standing history in the treatment of dermatologic disease. It is composed of various phytochemicals, which contribute to its wide-ranging function and clinical use. It has various…
Featured Articles
November 10, 2020

Oral Collagen Supplementation: A Systematic Review of Dermatological Applications

Nutrition is thought to play an important role in skin homeostasis. The use of nutraceuticals or “functional foods” in skincare along with technological innovations within the food industry has been…
Podcast Highlights
November 6, 2020

Treating the AD Patient During COVID-19

iTunes Google Play Stitcher TuneIn Dr. Peter Lio and Dr. Adam Friedman   Atopic dermatitis is a relentless, recurring, unreasonable, often recalcitrant inflammatory skin disease that impacts millions of children…

View the Latest Skin of Color, Anti-Aging, Aesthetic, and Medical Dermatology Articles Now

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Dermatology News

JDD Highlights

The July issue of the Journal of Drugs in Dermatology is available now. This month, we focus on Skin of Color, with special features on Anti-Aging, Aesthetic, and Medical Dermatology.
Read the JDD Now

Skin of Color, Anti-Aging, Aesthetic, and Medical Dermatology

The July issue of the Journal of Drugs in Dermatology is available now. This month, we focus on Skin of Color, with special features on Anti-Aging, Aesthetic, and Medical Dermatology.

Article Highlights

Editor's Picks

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Colloidal Oatmeal Part I: Clinical Efficacy in the Treatment of Atopic Dermatitis

| Atopic Dermatitis, Featured Articles, The Latest | No Comments
Colloidal oatmeal has a long-standing history in the treatment of dermatologic disease. It is composed of various phytochemicals, which contribute to its wide-ranging function and clinical use. It has various…

Oral Collagen Supplementation: A Systematic Review of Dermatological Applications

| Featured Articles | No Comments
Nutrition is thought to play an important role in skin homeostasis. The use of nutraceuticals or “functional foods” in skincare along with technological innovations within the food industry has been…

Treating the AD Patient During COVID-19

| Podcast Highlights | No Comments
iTunes Google Play Stitcher TuneIn Dr. Peter Lio and Dr. Adam Friedman   Atopic dermatitis is a relentless, recurring, unreasonable, often recalcitrant inflammatory skin disease that impacts millions of children…

The Latest Research & Discoveries in Acne, Rosacea, Anti-Aging, and Medical Dermatology

By Acne, JDD Highlights, Rosacea No Comments

Dermatology News

JDD Highlights

The June issue of the Journal of Drugs in Dermatology is available now. This month, we focus on Acne and Rosacea, with special features on Public Health, Anti-aging, Aesthetic, and Medical Dermatology.

Read the JDD Now

Acne, Rosacea, Public Health, Anti-Aging, Aesthetic, and Medical Dermatology

The June issue of the Journal of Drugs in Dermatology is available now. This month, we focus on Acne and Rosacea, with special features on Public Health, Anti-aging, Aesthetic, and Medical Dermatology.

Article Highlights

Editor's Picks

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Atopic DermatitisFeatured ArticlesThe Latest
November 16, 2020

Colloidal Oatmeal Part I: Clinical Efficacy in the Treatment of Atopic Dermatitis

Colloidal oatmeal has a long-standing history in the treatment of dermatologic disease. It is composed of various phytochemicals, which contribute to its wide-ranging function and clinical use. It has various…
Featured Articles
November 10, 2020

Oral Collagen Supplementation: A Systematic Review of Dermatological Applications

Nutrition is thought to play an important role in skin homeostasis. The use of nutraceuticals or “functional foods” in skincare along with technological innovations within the food industry has been…
Podcast Highlights
November 6, 2020

Treating the AD Patient During COVID-19

iTunes Google Play Stitcher TuneIn Dr. Peter Lio and Dr. Adam Friedman   Atopic dermatitis is a relentless, recurring, unreasonable, often recalcitrant inflammatory skin disease that impacts millions of children…

December Issue Highlights!

By JDD Highlights
The December 2019 JDD is here!
This month, we focus on anti-aging, aesthetics, and medical dermatology!  Take a look at our editorial highlights, editor’s picks, and more below:
  • The formation of a mnemonic that incorporates the most prevalent clinical features of PG could aid in accu­racy and speed of diagnosis in The 5 P’s of Pyoderma Gangrenosum (First Place Winner of the 9th Annual ARTE Poster Competition at ODAC)

     

     

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June 16, 2020

A Must-Read: The Business of Dermatology

Edited by Drs. Jeffrey S. Dover and Kavita Mariwalla, and authored by impressive experts in the field, The Business of Dermatology offers a comprehensive guide to opening, maintaining, and sustaining…
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June 1, 2020

Controversies in Photoprotection

Adam Friedman, MD, FAAD is Professor and Interim Chair of Dermatology and serves as Residency Program Director, Director of Translational Research, and Director of the Supportive OncodermatologyProgram in the Department…
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May 18, 2020

Does This Skin Cancer Really Need Mohs?

The discussion was led by Dr. Vishal Patel and Dr. Sailesh Konda, and was moderated by Dr. William Hanke. In recognition of National Skin Cancer Month, the Journal of Drugs…