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acne Archives - JDDonline - Journal of Drugs in Dermatology

NEW Webinar – Differentiating Approach to Acne Therapy: Women Vs. Men

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Featured Article

Featured Webinar

Join Leon H. Kircik, MD and Julie Harper, MD as they discuss the mechanisms by which androgen/AR regulate sebocyte activity in acne vulgaris.

  • October 27th, 2020
  • 7:00 PM – 8:00 PM EST
Register Now!

Join Drs. Leon H. Kircik, MD and Julie Harper, MD as they discuss Acne severity and grade (comedonal, papulopustular, mixed, nodular), skin type, presence of acne scarring and postinflammatory hyperpigmentation, menstrual cycle history (in women), and more, as well as the factors influencing treatment with classes of topical agents.

Acne vulgaris is a chronic inflammatory dermatologic disease affecting an estimated 80% of the population at some point in their life; 85% of adolescents and young adult s may experience acne and prevalent in adults with more adult women being afflicted than adult men, raising the possibility that gender difference in skin may influence the pathogenesis of acne and
treatment response.
Dermatologists indicate late-onset or adult -onset acne is becoming increasingly common in women in their 20s to 50s and research shows a large number of women over age 25 have acne and the prevalence of acne remains constant until age 44 at which time there is a decrease in incidence.
Join Drs. Leon H. Kircik, MD and Julie Harper, MD as they discuss Acne severity and grade (comedonal, papulopustular, mixed, nodular), skin type, presence of acne scarring and postinflammatory hyperpigmentation, menstrual cycle history (in women), and more, as well as the factors influencing treatment with classes of topical agents.
Register Now!

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What are the Skincare Benefits of Niacinamide?

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A 2016 study from Journal of Drugs in Dermatology suggests that a topical cream containing retinol 0.5% in combination with niacinamide, resveratrol, and hexylresorcinol is efficacious and tolerable for skin…

Oral Collagen Supplementation: A Systematic Review of Dermatological Applications

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800 patients who took up to 10 grams of collagen per day, experienced improvement in skin elasticity, moisture retention, and increased density of collagen fibers in the skin. Improvements in…

Impact of Iron-Oxide Containing Formulations Against Visible Light-Induced Skin Pigmentation in Skin of Color Individuals

| Aesthetics, Featured Articles, Photoprotection, Skin of Color | No Comments
In this study, the efficacy of two formulations containing iron oxide was evaluated in preventing visible light-induced pigmentation compared with a non-tinted mineral SPF 50+ sunscreen. Hawasatu Dumbuya PhD, Pearl…

Premiere Webinar Event: Recognizing the Role of The Sebaceous Gland in Acne

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Featured Article

Featured Webinar

Join Leon H. Kircik, MD and James Q. Del Rosso, DO, FAOCD, FAAD as they discuss the mechanisms by which androgen/AR regulate sebocyte activity in acne vulgaris.

Register Now!

Join Leon H. Kircik, MD and James Q. Del Rosso, DO, FAOCD, FAAD as they discuss the mechanisms by which androgen/AR regulate sebocyte activity in acne vulgaris.

Androgen and androgen receptor (AR) may play important roles in several skin related diseases including androgenetic alopecia and acne vulgaris and recent studies suggest AR and androgens play distinct roles in the skin pathogenesis, and AR seems to be a better target than androgens for the treatment of these skin diseases.

Tune in as Leon H. Kircik, MD and James Q. Del Rosso, DO, FAOCD, FAAD discuss the mechanisms by which androgen/AR regulate sebocyte activity in acne vulgaris, and how suppressing AR function by treating with antiandrogens alone, or in combination with antibiotics (i.e., to reduce bacterial infection) might be a potential therapeutic approach to treat acne more effectively.

The results of this open-label clinical study suggest that a topical cream containing retinol 0.5% in combination with niacinamide, resveratrol, and hexylresorcinol is efficacious and tolerable for skin brightening/anti-aging when used with a complementary skin care regimen including SPF 30 sun protection.

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What are the Skincare Benefits of Niacinamide?

| Aesthetics, Featured Articles | No Comments
A 2016 study from Journal of Drugs in Dermatology suggests that a topical cream containing retinol 0.5% in combination with niacinamide, resveratrol, and hexylresorcinol is efficacious and tolerable for skin…

Oral Collagen Supplementation: A Systematic Review of Dermatological Applications

| Aesthetics, Featured Articles | No Comments
800 patients who took up to 10 grams of collagen per day, experienced improvement in skin elasticity, moisture retention, and increased density of collagen fibers in the skin. Improvements in…

Impact of Iron-Oxide Containing Formulations Against Visible Light-Induced Skin Pigmentation in Skin of Color Individuals

| Aesthetics, Featured Articles, Photoprotection, Skin of Color | No Comments
In this study, the efficacy of two formulations containing iron oxide was evaluated in preventing visible light-induced pigmentation compared with a non-tinted mineral SPF 50+ sunscreen. Hawasatu Dumbuya PhD, Pearl…

Systemic Antibiotics in the Management of Acne: Issues and Considerations for Optimal Care

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JDD Podcast

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"Systemic Antibiotics in the Management of Acne: Issues and Considerations for Optimal Care"

Drs. Joslyn Kirby and Adam Friedman

 

WEEEEEEERE BACK! Join host Dr. Adam Friedman for lively and learned discussion with Dr. Joslyn Kirby on one of the most common, chronic, soul-crushing complaints… Acne Vulgaris. It is, from a pathophysiological standpoint, a biological sh*t show, but you need to understand it to develop the best treatment plans. We talk inflammation, first line approaches, setting patient expectations and compliance. We dive deep into the differences between broad-spectrum and narrow-spectrum antibiotics, when to use them, and for how long. (Spoiler alert: NOT TOO LONG!). In our efforts to be stewards of meaningful antibiotic use and adversaries of antimicrobial resistance, narrow-spectrum antibiotics are the future!

This enduring activity is supported by an independent medical education grant provided by Almirall, LLC.

Upon completion of this enduring, internet-based educational activity, participants should be able to:

  • Review current scientific understanding of pathophysiology of acne
  • Summarize acne treatment strategies utilizing systemic antibiotics
  • Differentiate safety and efficacy of broad and narrow spectrum antibiotics indicated for acne treatment
  • Cite the benefits of narrow spectrum antibiotic use in acne therapy
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Disclosures:
  • Adam Friedman, MD, FAAD – Grant/Research: Aclaris, CPN, Almirall. Consultant: SanovaWorks, Oakstone Institute, L’oreal, La Roche Posay, Galderma, Aveeno, Valeant, Microcures, Biogen, Pfizer, G&W Laboratories, Novartis, Occulus, Intraderm, Encore, Exeltis, Menlo, Lilly, Aclaris, Dermira, Berg, Allergan, Zylo Therapeutics, Hoth. Speaker’s Bureau: Regeneron, Dermira, Janssen, AbbVie. Major Stock Shareholder: Zylo, Minorcures.
  • Joslyn R. Sciacca Kirby, MD – No relevant disclosures.

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Understanding and Changing Patient Behavior and Minimizing Risk of UV Damage

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iTunes Google Play Stitcher TuneIn Drs. Sherry Pagoto and Adam Friedman   Why is is that we tend to do things we know are bad for us? Candy, alcohol, Tinder...the…

NEW from the JDD Podcast: “The Science of Sun Protection”

| Photoprotection, Podcast Highlights, Skin Cancer | No Comments
iTunes Google Play Stitcher TuneIn Dr. Neal Bhatia and Dr. Adam Friedman   Photoprotection works, plain and simple. Yet all too often we must defend good science, dispel unfounded myths,…

Support the (On)cause: A Practical Review of Supportive Oncodermatology

| Podcast Highlights, Skin Cancer | No Comments
iTunes Google Play Stitcher TuneIn Drs. Mario Lacouture and Adam Friedman   Cancer sucks, plain and simple. What is often overlooked is that the life saving/altering therapies often come with…

Once-Daily Polymeric Tazarotene 0.045% Lotion for Moderate-to-Severe Acne: Pooled Phase 3 Analysis by Sex

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Skin of Color Update

Featured Article

Acne is a common dermatologic condition, affecting up to 85% of adolescents and young adults.1 The prevalence of adult acne appears to be increasing in both females and males; however, there are differences in treatment needs and physiology between the sexes that should be taken into account when prescribing acne treatments.

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Data from these studies were pooled and analyzed post hoc to evaluate outcomes by sex

Leon H. Kircik MD, Linda Stein Gold MD, Kenneth Beer MD, Jerry Tan MD, Hilary Baldwin MD, Eric Guenin PharmD PHD MPH, Robert Kang MS, Jognson Varughesei

Acne is a common dermatologic condition, affecting up to 85% of adolescents and young adults.1 The prevalence of adult acne appears to be increasing in both females and males; however, there are differences in treatment needs and physiology between the sexes that should be taken into account when prescribing acne treatments. While most patients experience onset during adolescence, persistent adult acne is more common in female patients.

Additionally, females are more likely to experience recurrences of acne throughout their lives, requiring long-term maintenance treatment.3,4 In terms of skin physiology, males tend to have less epidermal water loss, higher sebum production, and a lower pH than females.5 In females, sebum production is not only lower, it also decreases with age leading to drier skin later in life.5 Along these lines, females are more likely to report dry, sensitive skin,4 which may become more apparent with age.6 These differences between female and male patients with acne could affect treatment efficacy, tolerability, or adherence.

Topical retinoids are the mainstay of acne treatment due to their comedolytic and anti-inflammatory properties.7 Several retinoids are commercially available (eg, tretinoin, adapalene, trifarotene, and tazarotene)1,8 but studies have shown that tazarotene 0.1% cream may be more effective than tretinoin 0.025% or adapalene 0.1% or 0.3% in treating acne.9-11 While the efficacy and safety of topical retinoids are well established,12,13 adverse effects such as irritation, erythema, peeling, and dryness can occur in the first weeks of treatment, especially at higher concentrations.7,12 To address these issues, a new tazarotene 0.045% lotion formulation was developed utilizing polymeric emulsion technology.14 An oil-in-water emulsion—structured by a three-dimensional mesh matrix containing tazarotene along with hydrating and moisturizing agents—allows for more uniform release and increased absorption of ingredients. This easily spreadable and easy-to-use lotion formulation also allows for a lower tazarotene concentration, and when combined with optimized delivery of active and hydrating ingredients, may improve tolerability.14

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Article Cited in this Post

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What are the Skincare Benefits of Niacinamide?

| Aesthetics, Featured Articles | No Comments
A 2016 study from Journal of Drugs in Dermatology suggests that a topical cream containing retinol 0.5% in combination with niacinamide, resveratrol, and hexylresorcinol is efficacious and tolerable for skin…

Oral Collagen Supplementation: A Systematic Review of Dermatological Applications

| Aesthetics, Featured Articles | No Comments
800 patients who took up to 10 grams of collagen per day, experienced improvement in skin elasticity, moisture retention, and increased density of collagen fibers in the skin. Improvements in…

Impact of Iron-Oxide Containing Formulations Against Visible Light-Induced Skin Pigmentation in Skin of Color Individuals

| Aesthetics, Featured Articles, Photoprotection, Skin of Color | No Comments
In this study, the efficacy of two formulations containing iron oxide was evaluated in preventing visible light-induced pigmentation compared with a non-tinted mineral SPF 50+ sunscreen. Hawasatu Dumbuya PhD, Pearl…

Acne, OCPs, and a Side Order of Practical Pearls for the Adolescent Patient

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JDD Podcast

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"Acne, OCPs, and a Side Order of Practical Pearls for the Adolescent Patient"

Dr. Adam Friedman and Dr. Lawrence Eichenfield

JDD Podcast host Dr. Adam Friedman gets first-hand insight from internationally acclaimed pediatric dermatologist Dr. Lawrence Eichenfield on his recent study entitled “Hormonal Contraceptives and Acne: A Retrospective Analysis of 2147 Patients” published in the June 2016 edition of the Journal of Drugs of Dermatology.

Want a refresher on the use of OCPs in Acne? Interested in learning how to initiate a patient based survey study? Just curious how a leader in the field gets an uninterested adolescent to be compliant and engaged in his/her acne care? These are just a few of the practical pearls provided.

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Article Cited in this Post
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Understanding and Changing Patient Behavior and Minimizing Risk of UV Damage

| Podcast Highlights, Skin Cancer | No Comments
iTunes Google Play Stitcher TuneIn Drs. Sherry Pagoto and Adam Friedman   Why is is that we tend to do things we know are bad for us? Candy, alcohol, Tinder...the…

NEW from the JDD Podcast: “The Science of Sun Protection”

| Photoprotection, Podcast Highlights, Skin Cancer | No Comments
iTunes Google Play Stitcher TuneIn Dr. Neal Bhatia and Dr. Adam Friedman   Photoprotection works, plain and simple. Yet all too often we must defend good science, dispel unfounded myths,…

Support the (On)cause: A Practical Review of Supportive Oncodermatology

| Podcast Highlights, Skin Cancer | No Comments
iTunes Google Play Stitcher TuneIn Drs. Mario Lacouture and Adam Friedman   Cancer sucks, plain and simple. What is often overlooked is that the life saving/altering therapies often come with…

The Latest Research & Discoveries in Acne, Rosacea, Anti-Aging, and Medical Dermatology

By Acne, JDD Highlights, Rosacea No Comments

Dermatology News

JDD Highlights

The June issue of the Journal of Drugs in Dermatology is available now. This month, we focus on Acne and Rosacea, with special features on Public Health, Anti-aging, Aesthetic, and Medical Dermatology.

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Acne, Rosacea, Public Health, Anti-Aging, Aesthetic, and Medical Dermatology

The June issue of the Journal of Drugs in Dermatology is available now. This month, we focus on Acne and Rosacea, with special features on Public Health, Anti-aging, Aesthetic, and Medical Dermatology.

Article Highlights

Editor's Picks

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JDD Webinars
October 14, 2020

NEW Webinar – Differentiating Approach to Acne Therapy: Women Vs. Men

Join Leon H. Kircik, MD and Julie Harper, MD as they discuss the mechanisms by which androgen/AR regulate sebocyte activity in acne vulgaris. October 27th, 2020 7:00 PM - 8:00…
Podcast HighlightsSkin Cancer
October 7, 2020

Understanding and Changing Patient Behavior and Minimizing Risk of UV Damage

iTunes Google Play Stitcher TuneIn Drs. Sherry Pagoto and Adam Friedman   Why is is that we tend to do things we know are bad for us? Candy, alcohol, Tinder...the…
Podcast
October 6, 2020

Understanding and Changing Patient Behavior and Minimizing Risk of UV Damage

Episode 2 of a 2-Part Series: "Sun Protection: A Review of Current Interventions and Barriers to Changing Patient Attitude and Behavior" Why is is that we tend to do things…

Skin Immune Response: Friend or Foe?

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JDD Multimedia

Translational Lecture Series

Dr. Jenny Kim will review skin’s important role as an immune organ and what happens when dysregulation occurs.

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Skin Immune Response: Friend or Foe? - Exploring the Role of Inflammation and Microbes in Acne Pathogenesis

featuring Dr. Jenny Kim

In this edition of the GW Translational Lecture Series, Dr. Jenny Kim reviews the skin’s important role as an immune organ and what happens when dysregulation occurs.

Presenter

  • Jenny Kim, MD, PhD is a Professor of Clinical Medicine at the David Geffen School of Medicine at UCLA and Chief of Dermatology at the Greater Los Angeles Healthcare System Veterans Affairs.

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NEW Webinar – Differentiating Approach to Acne Therapy: Women Vs. Men

| JDD Webinars | No Comments
Join Leon H. Kircik, MD and Julie Harper, MD as they discuss the mechanisms by which androgen/AR regulate sebocyte activity in acne vulgaris. October 27th, 2020 7:00 PM - 8:00…

Understanding and Changing Patient Behavior and Minimizing Risk of UV Damage

| Podcast Highlights, Skin Cancer | No Comments
iTunes Google Play Stitcher TuneIn Drs. Sherry Pagoto and Adam Friedman   Why is is that we tend to do things we know are bad for us? Candy, alcohol, Tinder...the…

Understanding and Changing Patient Behavior and Minimizing Risk of UV Damage

| Podcast | No Comments
Episode 2 of a 2-Part Series: "Sun Protection: A Review of Current Interventions and Barriers to Changing Patient Attitude and Behavior" Why is is that we tend to do things…

November JDD Highlights

By JDD Highlights
The November 2019 JDD is here!
This month, we focus on lasers, light sources, and devices! Take a look at our editorial highlights, editor’s picks, and more below:
Get More from the JDD - Subscribe Today!

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Derm Community
June 16, 2020

A Must-Read: The Business of Dermatology

Edited by Drs. Jeffrey S. Dover and Kavita Mariwalla, and authored by impressive experts in the field, The Business of Dermatology offers a comprehensive guide to opening, maintaining, and sustaining…
Derm CommunityODACPhotoprotectionSkin Cancer
June 1, 2020

Controversies in Photoprotection

Adam Friedman, MD, FAAD is Professor and Interim Chair of Dermatology and serves as Residency Program Director, Director of Translational Research, and Director of the Supportive OncodermatologyProgram in the Department…
Derm CommunityODACSkin Cancer
May 18, 2020

Does This Skin Cancer Really Need Mohs?

The discussion was led by Dr. Vishal Patel and Dr. Sailesh Konda, and was moderated by Dr. William Hanke. In recognition of National Skin Cancer Month, the Journal of Drugs…