Barrier boost with benefits – new topical cream raises filaggrin, hyaluronic acid and lipids while improving tolerability
A novel topical cream moisturizer produced meaningful biological and clinical improvements in both laboratory and human studies. In preclinical models the formulation increased filaggrin by 77%, hyaluronic acid by 157% and epidermal lipids by 30% versus untreated controls (P<0.05) and upregulated lipid pathways tied to barrier function. Clinical studies showed progressive increases in surface hydration, reductions in transepidermal water loss over four weeks and sustained hydration after a 3‑day regression challenge.
Daily application on clinically sensitive skin improved patient‑reported skin appearance and feel without increasing irritation, and was associated with better quality‑of‑life metrics and favorable aesthetics. Taken together, the data support this cream as an effective adjunctive, barrier‑supportive product for patients with atopic dermatitis, rosacea or cosmetic intolerance, particularly when improving tolerability and appearance is a priority.
Consider integrating a ceramide‑rich, tolerability‑focused moisturizer like this into treatment plans for patients with compromised barrier function and sensitized skin, and monitor clinical response and patient experience over the first month.
J Drugs Dermatol. 2025;24(10):1029-1035. doi:10.36849/JDD.9386
Blog write-up assisted by AI
