As seen here, pyogenic granulomas present as friable or ulcerated pink to red papulonodules which bleed spontaneously or after trauma. A hyperpigmented base may surround lesions in darker skin tones due to post-inflammatory changes. Clinical history of rapid growth, oral retinoid use, or pregnancy help to distinguish pyogenic granulomas from similar appearing growths, such as amelanotic melanomas, glomus tumors, or traumatized hemangiomas.

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