Meta-analysis of RCTs Reveals Significant Gains In Hydration And Elasticity – With Wrinkle Reduction On The Horizon
A new meta-analysis of seven randomized controlled trials offers dermatologists a fresh look at oral hyaluronic acid’s role in skin health. By pooling standardized data, researchers found that daily HA supplementation delivers statistically significant improvements in skin hydration and elasticity, alongside a measurable decrease in wrinkle depth. Although trends toward enhanced firmness and reduced transepidermal water loss did not meet statistical significance, the consistent direction of results suggests true biological promise.
These findings invite practicing dermatologists to weigh oral HA alongside established topical and injectable therapies. Rather than a standalone panacea, systemic HA may serve as an adjunct in anti-aging regimens, particularly for patients seeking non-invasive options. To translate this evidence into practice, consider monitoring patient outcomes, contributing to larger clinical trials, and staying informed on emerging data. Exploring oral HA could refine your treatment toolbox and advance patient-centered care.
J Drugs Dermatol. 2025;24(9):910-919. doi:8542
Blog write-up assisted by AI
