Featured Articles

Oral Collagen Supplementation: A Systematic Review of Dermatological Applications

By November 10, 2020November 27th, 2020No Comments

Featured Article

Featured Article

Nutrition is thought to play an important role in skin homeostasis. The use of nutraceuticals or “functional foods” in skincare along with technological innovations within the food industry has been rising.

Read more

Nutrition is thought to play an important role in skin homeostasis. The use of nutraceuticals or “functional foods” in skincare along with technological innovations within the food industry has been rising.

Franchesca D. Choi BS RPh, Calvin T. Sung BS, Margit L.W. Juhasz MD, Natasha Atanaskova Mesinkovska MD PhD

 

 In 2016, the collagen market was valued at an estimated 3.71 billion USD and is projected to reach 6.63 billion USD by 2025. Collagen supplements, originating from various sources (eg, porcine, bovine, marine) and available in numerous formulations (eg, protein, gelatin, hydrolysate, peptides), are marketed as improving skin integrity and modulating skin aging. However, even with this increase in patient interest and market share, the use of collagen supplementation in dermatology remains controversial due to the lack of regulation on quality and quantity of ingredients in over-the-counter collagen supplements, as well as minimal peer-reviewed literature on the subject.

Fortunately, there are increasing numbers of clinical studies regarding potential effects of collagen-based dietary supplements on skin. Collagen is the most abundant component of the extracellular matrix constituting 75% of skin’s dry weight.5 Qualitative and quantitative decline in collagen is associated with cutaneous aging.6 Collagen protein is a right-handed triple helix of parallel polypeptides where every third amino acid residue is glycine (Gly) resulting in X-Y-Gly triplets, where X andY are frequently proline (Pro) and 4-hydroxyproline (Hyp; an amino acid sub- unit unique to collagen), respectively,7 making Pro-Hyp-Gly the most common amino acid triplet unit found in collagen

Native, animal collagen can be extracted from connective tissue in various forms.10 When denatured by heat, collagen forms gelatin, which has been used for centuries as a food source and traditional medicine in Europe and China.

Further enzymatic hydrolysis of gelatin produces collagen hydrolysates (CH) composed of peptides of varying lengths. CH has a lower molecular weight than gelatin, higher water-solubility, and no gelation properties at ambient temperatures, allowing CH to be conveniently formulated into liquid drinks and jelly sticks for oral consumption. In the past decade, CHs have gained popularity as a nutraceutical supplement.

Read Full Article Now
Article Cited in this Post

You May Also Like

Journal of Drugs in Dermatology JDD Article About Podoconiosis: Review of this Unusual Cause of Lower Extremity Lymphedema and its Global Health Burden

Podoconiosis: Review of this Unusual Cause of Lower Extremity Lymphedema and its Global Health Burden

| Featured Articles, Global Health, Latest News, The Latest | No Comments
July Article Spotlight In parts of the world where red clay soil coats the ground, podoconiosis—non-filarial elephantiasis—continues to devastate lives. This neglected tropical disease affects nearly 4 million people globally…
Journal of Drugs in Dermatology JDD Article About Addressing the Root Causes of Female Hair Loss and Non-Pharmaceutical Interventions

Addressing the Root Causes of Female Hair Loss and Non-Pharmaceutical Interventions

| Atopic Dermatitis, Featured Articles, Latest News, The Latest | No Comments
Beyond Minoxidil: Is It Time to Rethink Female Hair Loss Treatment? More than half of postmenopausal women, and a significant percentage of younger, healthy women, struggle with visible hair loss,…
Journal of Drugs in Dermatology JDD Article About Socioeconomic Disparities in Gentle Skin Care Access for Atopic Dermatitis: Affordability and Pharmacy Deserts. Image is of deeper skin tone patient’s back covered with erythema, red atopic dermatitis.

Socioeconomic Disparities in Gentle Skin Care Access for Atopic Dermatitis: Affordability and Pharmacy Deserts

| Atopic Dermatitis, Featured Articles, Latest News, The Latest | No Comments
Access Inequity in Atopic Dermatitis Care: Are Your Patients Getting Left Behind? Gentle skin care is a foundation of atopic dermatitis (AD) treatment, but what happens when patients can’t afford,…

Leave a Reply