Featured Articles

Oral Collagen Supplementation: A Systematic Review of Dermatological Applications

By November 10, 2020November 27th, 2020No Comments

Featured Article

Featured Article

Nutrition is thought to play an important role in skin homeostasis. The use of nutraceuticals or “functional foods” in skincare along with technological innovations within the food industry has been rising.

Read more

Nutrition is thought to play an important role in skin homeostasis. The use of nutraceuticals or “functional foods” in skincare along with technological innovations within the food industry has been rising.

Franchesca D. Choi BS RPh, Calvin T. Sung BS, Margit L.W. Juhasz MD, Natasha Atanaskova Mesinkovska MD PhD

 

 In 2016, the collagen market was valued at an estimated 3.71 billion USD and is projected to reach 6.63 billion USD by 2025. Collagen supplements, originating from various sources (eg, porcine, bovine, marine) and available in numerous formulations (eg, protein, gelatin, hydrolysate, peptides), are marketed as improving skin integrity and modulating skin aging. However, even with this increase in patient interest and market share, the use of collagen supplementation in dermatology remains controversial due to the lack of regulation on quality and quantity of ingredients in over-the-counter collagen supplements, as well as minimal peer-reviewed literature on the subject.

Fortunately, there are increasing numbers of clinical studies regarding potential effects of collagen-based dietary supplements on skin. Collagen is the most abundant component of the extracellular matrix constituting 75% of skin’s dry weight.5 Qualitative and quantitative decline in collagen is associated with cutaneous aging.6 Collagen protein is a right-handed triple helix of parallel polypeptides where every third amino acid residue is glycine (Gly) resulting in X-Y-Gly triplets, where X andY are frequently proline (Pro) and 4-hydroxyproline (Hyp; an amino acid sub- unit unique to collagen), respectively,7 making Pro-Hyp-Gly the most common amino acid triplet unit found in collagen

Native, animal collagen can be extracted from connective tissue in various forms.10 When denatured by heat, collagen forms gelatin, which has been used for centuries as a food source and traditional medicine in Europe and China.

Further enzymatic hydrolysis of gelatin produces collagen hydrolysates (CH) composed of peptides of varying lengths. CH has a lower molecular weight than gelatin, higher water-solubility, and no gelation properties at ambient temperatures, allowing CH to be conveniently formulated into liquid drinks and jelly sticks for oral consumption. In the past decade, CHs have gained popularity as a nutraceutical supplement.

Read Full Article Now
Article Cited in this Post

You May Also Like

Journal of Drugs in Dermatology JDD Article About Top Chief Complaints and Diagnoses for Outpatient Dermatology Patients of Color

Top Chief Complaints and Diagnoses for Outpatient Dermatology Patients of Color

| Featured Articles, Latest News, Skin of Color, The Latest | No Comments
Did you miss it? By 2044, people with skin of color (SOC) will make up the majority of the U.S. population—but dermatology still lags behind in addressing their unique needs.…
Journal of Drugs in Dermatology JDD Article About Improvement in Skin Moisturization and Lack of Barrier Damage Following Treatment With Clascoterone Cream 1%

Improvement in Skin Moisturization and Lack of Barrier Damage Following Treatment With Clascoterone Cream 1%

| Acne, Featured Articles, Latest News, The Latest | No Comments
Acne Treatment Without the Dry-Out: Clascoterone Cream 1% Proves Gentle on the Skin Barrier Topical acne meds often come with an unfortunate side effect: dry, irritated skin that leaves patients…
Journal of Drugs in Dermatology JDD Article About The State of the Clinical Management Union: A Cross-Sectional Survey of Persons With Hidradenitis Suppurativa

The State of the Clinical Management Union: A Cross-Sectional Survey of Persons With Hidradenitis Suppurativa

| Acne, Featured Articles, Latest News, The Latest | No Comments
April Issue Must-Read! Hidradenitis suppurativa (HS) isn’t just painful—it’s deeply isolating. And new data reveals why: the majority of people living with HS don’t feel heard, treated, or informed. In a…

Leave a Reply