Oral Antibiotics for Acne: Basic Concepts & Practical Considerations

Drs. Mahmoud Ghannoum, Emmy Graber & Adam Friedman

Antibiotic use for inflammatory skin diseases is a staple in dermatology. Like milk is the answer to a chunky peanut butter sandwich (just go with me on this), so too have tetracycline antibiotics been married to the management of Acne Vulgaris. And just as that delicious combo comes at a fattening cost, the overuse and abuse of antibiotics has an impressive and significant impact both on the risk for antimicrobial resistance and gut/cutaneous dysbiosis. To get to the piloseabeous unit of the matter, JDD Podcast host Dr. Adam Friedman picks the brains of AAA experts Dr. Emmy Graber and Dr. Mahmoud Ghannoum to provide a true bench to bedside review of the issues at hand. Pop in to learn how to interpret minimum inhibitory concentrations (MIC), understand newly identified information on dysbiosis (including impaired microbiota), and appreciate the implications of indiscriminate use of broad-spectrum antibiotics in acne therapy including the clinical consequence of antibiotic resistance and benefits of narrow-spectrum agents.

Upon completion of this podcast participants should be able to:

  • Describe the differences between antibiotic types and their use in acne therapy
  • Discuss interpretation and measurement of MIC, resistance and dysbiosis
  • Summarize the clinical implications of antibiotic resistance
  • Summarize the clinical implications of dysbiosis

This enduring activity is supported by an independent medical education grant provided by Almirall, LLC.


Adam Friedman, MD, FAAD – Grant/Research: Aclaris, CPN, Almirall. Consultant: SanovaWorks, Oakstone Institute, L’oreal, La Roche Posay, Galderma, Aveeno, Valeant, Microcures, Biogen, Pfizer, G&W Laboratories, Novartis, Occulus, Intraderm, Encore, Exeltis, Menlo, Lilly, Aclaris, Dermira, Berg, Allergan, Zylo Therapeutics, Hoth. Speakers’ Bureau: Regeneron, Dermira, Janssen, AbbVie. Major Stock Shareholder: Zylo, Minorcures.

Mahmoud Ghannoum, PhD – Grant/Research: Almirall. Consultant: Almirall.

Emmy M. Graber, MD, MBA – Grant/Research: Ortho Dermatologics. Consultant: Almirall, Digital Diagnostics, Sebacia, SolGel. Speakers’ Bureau: Almirall.