Featured Articles

Once-Daily Polymeric Tazarotene 0.045% Lotion for Moderate-to-Severe Acne: Pooled Phase 3 Analysis by Sex

By July 27, 2020No Comments

Skin of Color Update

Featured Article

Acne is a common dermatologic condition, affecting up to 85% of adolescents and young adults.1 The prevalence of adult acne appears to be increasing in both females and males; however, there are differences in treatment needs and physiology between the sexes that should be taken into account when prescribing acne treatments.

Read more

Data from these studies were pooled and analyzed post hoc to evaluate outcomes by sex

Leon H. Kircik MD, Linda Stein Gold MD, Kenneth Beer MD, Jerry Tan MD, Hilary Baldwin MD, Eric Guenin PharmD PHD MPH, Robert Kang MS, Jognson Varughesei

Acne is a common dermatologic condition, affecting up to 85% of adolescents and young adults.1 The prevalence of adult acne appears to be increasing in both females and males; however, there are differences in treatment needs and physiology between the sexes that should be taken into account when prescribing acne treatments. While most patients experience onset during adolescence, persistent adult acne is more common in female patients.

Additionally, females are more likely to experience recurrences of acne throughout their lives, requiring long-term maintenance treatment.3,4 In terms of skin physiology, males tend to have less epidermal water loss, higher sebum production, and a lower pH than females.5 In females, sebum production is not only lower, it also decreases with age leading to drier skin later in life.5 Along these lines, females are more likely to report dry, sensitive skin,4 which may become more apparent with age.6 These differences between female and male patients with acne could affect treatment efficacy, tolerability, or adherence.

Topical retinoids are the mainstay of acne treatment due to their comedolytic and anti-inflammatory properties.7 Several retinoids are commercially available (eg, tretinoin, adapalene, trifarotene, and tazarotene)1,8 but studies have shown that tazarotene 0.1% cream may be more effective than tretinoin 0.025% or adapalene 0.1% or 0.3% in treating acne.9-11 While the efficacy and safety of topical retinoids are well established,12,13 adverse effects such as irritation, erythema, peeling, and dryness can occur in the first weeks of treatment, especially at higher concentrations.7,12 To address these issues, a new tazarotene 0.045% lotion formulation was developed utilizing polymeric emulsion technology.14 An oil-in-water emulsion—structured by a three-dimensional mesh matrix containing tazarotene along with hydrating and moisturizing agents—allows for more uniform release and increased absorption of ingredients. This easily spreadable and easy-to-use lotion formulation also allows for a lower tazarotene concentration, and when combined with optimized delivery of active and hydrating ingredients, may improve tolerability.14

Read Article Now
Article Cited in this Post

You May Also Like

Journal of Drugs in Dermatology JDD Article About Assessing Patient Preferences for Atopic Dermatitis Treatment: A Review Article of Discrete Choice Experiments

Assessing Patient Preferences for Atopic Dermatitis Treatment: A Review Article of Discrete Choice Experiments

| Featured Articles, The Latest | No Comments
JDD Article Highlights Struggling with treatment adherence in your atopic dermatitis (AD) patients? AD is a widespread inflammatory skin condition, but even with various treatment options, poor adherence - especially to…
Journal of Drugs in Dermatology JDD article about Dermatologic Procedures for the Treatment of Seborrheic Dermatitis

Dermatologic Procedures for the Treatment of Seborrheic Dermatitis

| Featured Articles, The Latest | No Comments
Did You Miss It? Published early online in August, the JDD article titled “Dermatologic Procedures for the Treatment of Seborrheic Dermatitis” reviews alternative dermatologic procedures for treating Seborrheic Dermatitis (SD), offering clinicians…
Journal of Drugs in Dermatology JDD article titled The ABCs of JAKis: A Clinician's Guide to Safety and Monitoring of the Systemic JAK Inhibitors

The ABCs of JAKis: A Clinician’s Guide to Safety and Monitoring of the Systemic JAK Inhibitors

| Featured Articles, The Latest | No Comments
JDD Article Highlight Curious about the latest in dermatology treatments? Janus Kinase Inhibitors (JAKis) are gaining traction as a powerful tool for various skin conditions—but there’s more to the story.…

Leave a Reply