Issue Archive
October 2021 | Volume 20 | Issue 10
Original Articles
Rationale and Preclinical Evaluation of a Multimodal Topical Body Skincare Product for Toning and Tightening
A novel tightening and toning cream (TTC) was designed to improve body skin quality at multiple levels by engaging several key pathways that contribute to skin function, strength, and integrity. Evalu...
Read MoreA New Approach to Thread Facelifting
Background: Facial rejuvenation has traditionally been achieved by repositioning soft tissue via invasive surgery.
Objectives: The present work describes a thread-based, face-lifting (TBFL) tech...
Read MoreFifty Years of Minocycline and Its Evolution: A Dermatological Perspective
2021 is the 50th anniversary of the FDA approval of minocycline (MCN). While many other antibiotics have become obsolete during this time, MCN continues to be quite useful. In dermatology, MCN is used...
Read MoreDevelopment of a Tape-Stripping Liquid Chromatography-Mass Spectrometry Method for Evaluating Skin Deposition of Topical Tazarotene
Background: Standard in vitro and ex vivo techniques for evaluating topical drug penetration utilize skin that is physiologically unlike living skin and cannot assess intra-dermal drug deposition. We ...
Read MoreComparison of Modern Super Wide Field Microscopy Systems in Mohs Surgery
Microscopic interpretation of frozen tissue sections is fundamental to Mohs micrographic surgery. Mohs surgeons spend a significant portion of their day at the microscope. Eye strain and fatigue, in a...
Read MoreThe Psychosocial Burden Associated With and Effective Treatment Approach for Atopic Dermatitis: A Literature Review
Atopic Dermatitis (AD) is chronic relapsing inflammatory skin condition that is marked by a high degree of psychosocial and emotional burden in both pediatric and adult populations. In addition to phy...
Read MoreComparison of Modern Super Wide Field Microscopy Systems in Mohs Surgery
Microscopic interpretation of frozen tissue sections is fundamental to Mohs micrographic surgery. Mohs surgeons spend a significant portion of their day at the microscope. Eye strain and fatigue, in a...
Read MoreTherapeutic Recommendations for the Treatment of Toenail Onychomycosis in the US
Background: Onychomycosis affects around 14% of individuals in North America and Europe and is undertreated. Treatment is challenging as toenail growth can take 12–18 months, the nail plate may ...
Read MoreComparison of Modern Super Wide Field Microscopy Systems in Mohs Surgery
Microscopic interpretation of frozen tissue sections is fundamental to Mohs micrographic surgery. Mohs surgeons spend a significant portion of their day at the microscope. Eye strain and fatigue, in a...
Read MoreThe Psychosocial Burden Associated With and Effective Treatment Approach for Atopic Dermatitis: A Literature Review
Atopic Dermatitis (AD) is chronic relapsing inflammatory skin condition that is marked by a high degree of psychosocial and emotional burden in both pediatric and adult populations. In addition to phy...
Read MoreDevelopment of a Tape-Stripping Liquid Chromatography-Mass Spectrometry Method for Evaluating Skin Deposition of Topical Tazarotene
Background: Standard in vitro and ex vivo techniques for evaluating topical drug penetration utilize skin that is physiologically unlike living skin and cannot assess intra-dermal drug deposition. We ...
Read MoreIncobotulinumtoxinA Demonstrates Safety and Prolonged Duration of Effect in a Dose-Ranging Study for Glabellar Lines
Background: To further explore clinical trial results indicating increasing doses of botulinum toxin A prolong duration of effect, a 2-stage, phase 2, randomized, double-blind study investigated the d...
Read MorePilot Study to Assess the Efficacy and Safety of a Novel, Bioelectric Muscle Activation Device for Muscle Toning and Fat Reduction
Background and Aims: Stimulation of muscles for improved strength and tone has historically been achieved using electro-muscular stimulation. Discomfort often limited the amount of current applied the...
Read MoreA Comparison of Alternative Medicine Users and Non-Users in Patients With Hidradenitis Suppurativa
Background: Hidradenitis suppurativa patients often seek non-prescription therapies.
Objective: To determine the prevalence of alternative medicine use and characterize the differences between p...
Read MoreBiological Therapy Interruption and Re-Treatment in Chronic Plaque Psoriasis
While biological treatments for chronic plaque psoriasis should be administered continuously to maximize and maintain efficacy, interruptions in therapy may be necessary for a number of reasons. We re...
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Features
Holistic and Integrative Methods for Diagnosing and Treating the Underlying Causes of Inflammatory Skin Diseases
While the majority of patients are helped by current dermatologic therapy, there are a number of patients who find no relief, or are afraid of the side effects of powerful immunosuppressants that do n...
Read MoreCharacteristics of Patients Initiating Guselkumab for Plaque Psoriasis in the Symphony Health Claims Database
Guselkumab is approved by the Food and Drug Administration for the treatment of moderate-to-severe plaque psoriasis. However, characteristics of patients initiating guselkumab in a real-world setting ...
Read MoreTreating Cutaneous Immune-Related Adverse Events from Immune Checkpoint Blockade
Immune checkpoint inhibitors (ICPis) have revolutionized outcomes in various advanced malignancies. Therapeutic restoration of a robust T-cell response against malignant cells is also at the root of d...
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Case Reports
Successful Use of Tildrakizumab for Treatment of Palmoplantar Pustulosis: A Case Report
Palmoplantar pustulosis (PPP) is a rare, recurrent skin disorder that presents a major challenge to clinical therapy. We report a case of a 69-year-old woman with a 20-year history of psoriasis with s...
Read MoreSuccessful Treatment of Brunsting-Perry Cicatricial Pemphigoid With Dupilumab
Brunsting-Perry is a rare variant of cicatricial pemphigoid, characterized by subepidermal bullae localized to the head and neck. Currently, treatment relies on non-specific immunosuppression, which i...
Read MoreSuccessful Treatment of Brunsting-Perry Cicatricial Pemphigoid With Dupilumab
Brunsting-Perry is a rare variant of cicatricial pemphigoid, characterized by subepidermal bullae localized to the head and neck. Currently, treatment relies on non-specific immunosuppression, which i...
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Supplements
FULL SUPPLEMENT: TIRBANIBULIN 1% OINTMENT FOR ACTINIC KERATOSIS LESS PAIN, MORE GAIN
Topical agents for actinic keratosis (AK), along with cryotherapy and phototherapy, are the most commonly used therapies for areas of skin with multiple AKs. Multiple options for the topical treatment...
Read MoreINDIVIDUAL ARTICLE: The Importance of Local Tolerability and Duration of Therapy in Topical Actinic Keratosis Treatment
Actinic keratoses (AK) are among the most common dermatologic presentations, with estimates suggesting that they account for approximately 15 percent of dermatologic diagnoses in the US.1 Incidence of...
Read MoreINDIVIDUAL ARTICLE: Safety and Tolerability of Topical Agents for Actinic Keratosis: A Systematic Review of Phase 3 Clinical Trials
Background: Topical agents for actinic keratosis (AK), along with cryotherapy and phototherapy, are the most commonly used therapies for areas of skin with multiple AKs. Multiple options for the topic...
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