Issue Archive
March 2016 | Volume 15 | Issue 3
Original Articles
Improvement of Nail and Scalp Psoriasis Using Apremilast in Patients With Chronic Psoriasis: Phase 2b and 3, 52-Week Randomized, Placebo-Controlled Trial Results
INTRODUCTION: A significant portion of patients with psoriasis have scalp and nail involvement. It has been reported that 40% to 45% of patients with psoriasis have nail psoriasis, and up to 80% have ...
Read MoreOnychomycosis: Strategies to Minimize Recurrence
Recurrence (relapse or re-infection) in onychomycosis is common, occurring in 10% to 53% of patients. However, data on prevalence is limited as few clinical studies follow patients beyond 12 months. I...
Read MoreEfficacy and Safety of Imiquimod 3.75% from Lmax in Actinic Keratosis According to Fitzpatrick Skin Type
BACKGROUND: Imiquimod 3.75% is an effective actinic keratosis (AK) treatment that detects and clears clinical and subclinical lesions across an entire sun-exposed field such as the full face or baldin...
Read MoreComparison of Guidelines for the Use of Cyclosporine for Psoriasis: A Critical Appraisal and Comprehensive Review
There are several well-established guidelines for the treatment of psoriasis. Guidelines have been proposed in the United States by the American Academy of Dermatology (AAD), in Europe by the European...
Read MoreCosts of Common Psoriasis Medications, 2010-2014
BACKGROUND: Costs for psoriasis have increased in recent years, in part due to the introduction of biologic agents.
OBJECTIVE: To identify the most common and most costly (from the payer perspe...
Read MoreAnti-IL-17 Agents for Psoriasis: A Review of Phase III Data
BACKGROUND: Studies investigating the molecular basis of psoriasis have established the central roles of TNFa, interleukin (IL)-12, IL-22 and IL-23, and now there is increasing evidence that IL-17 pla...
Read MoreA Review of Indigo Naturalis as an Alternative Treatment for Nail Psoriasis
INTRODUCTION: Nail psoriasis is challenging to treat. The few currently available therapies are limited in efficacy, and often produce unfavorable side effects. A plant extract widely used in Traditi...
Read MoreOver 25 Years of Clinical Experience With Ivermectin: An Overview of Safety for an Increasing Number of Indications
Although the broad-spectrum anti-parasitic effects of the avermectin derivative ivermectin are well documented, its anti-inflammatory activity has only recently been demonstrated. For over 25 years, i...
Read MoreImprovement in Extensive Moderate Plaque Psoriasis With a Novel Emollient Spray Formulation of Betamethasone Dipropionate 0.05%
BACKGROUND: A novel formulation of 0.05% betamethasone dipropionate in an emollient spray vehicle (DFD-01) was developed to deliver steroid to the skin layers most affected by psoriasis.
OBJECTI...
Read MoreEffectiveness of Subcutaneous Methotrexate in Chronic Plaque Psoriasis
BACKGROUND: Oral methotrexate (MTX) has been a first line systemic agent in the treatment of chronic plaque psoriasis (CPP) for more than 50 years. Parenteral MTX, administered as a subcutaneous (SC) ...
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Features
Clinical Trial Review
Clinical Trial Review is a JDD department designed to provide physicians with information on drugs and devices undergoing clinical testing. It is our goal to inform the reader of the status of select...
Read MorePipeline Previews
Pipeline Previews brings to you information on the newest drugs and medical products as they become available to the dermatologic community. This department may include additional information from th...
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Case Reports
Treatment of Imiquimod Resistant Epidermodysplasia Verruciformis With Ingenol Mebutate
BACKGROUND: Epidermodysplasia verruciformis (EV) is a rare genetic disorder characterized by widespread human papillomavirus (HPV) associated lesions and an increase susceptibility to cutaneous malign...
Read MorePercutaneous Selective Neuromodulation via Monopolar Radiofrequency for Glabellar Lines: A Case Study
INTRODUCTION: Injectable botulinum toxin is a safe, effective, and popular therapy that blocks neural impulses to achieve a desired effect. Using monopolar RF, percutaneous selective neuromodulation c...
Read MoreSevere Small-Vessel Vasculitis Temporally Associated With Administration of Ustekinumab
Vasculitis may be caused by infection, medications, systemic diseases, malignancy, or occur as an idiopathic condition. In cases of drug-induced vasculitis, it is essential to identify and discontinue...
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