Influenza Vaccination and Arm Nodules: Uncovering a Hidden Risk
A large propensity-matched cohort study using TriNetX data found that intramuscular influenza vaccination carries a 32% higher risk of developing subcutaneous nodules (HR 1.32; 95% CI: 1.28-1.37) and a 57% increased risk of upper-arm lipomas (HR 1.57; 95% CI: 1.28-1.93) compared to unvaccinated patients. These localized cutaneous reactions, though rare, highlight the critical role of proper injection technique in minimizing post-vaccine complications.
Clinicians should stay alert for nodules and lipomatous growths following flu shots and reinforce best practices in intramuscular administration. Read the full paper to learn more.
J Drugs Dermatol. 2025;24(10):974-978. doi:10.36849/JDD.8989
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