Acne Treatment Without the Dry-Out: Clascoterone Cream 1% Proves Gentle on the Skin Barrier
Topical acne meds often come with an unfortunate side effect: dry, irritated skin that leaves patients dreading their routine. But what if treating acne didn’t mean compromising skin barrier health?
A recent split-face study offers good news: clascoterone cream 1% not only fights acne—it helps the skin stay hydrated. After just two weeks of twice-daily application, participants had significantly higher moisture levels (as measured by corneometry) on the treated side of the face compared to the untreated side. Importantly, there was no increase in transepidermal water loss (TEWL)—meaning the skin barrier stayed intact.
Even better? Tolerability was stellar. Participants reported almost no dryness, redness, or irritation—making this an acne treatment option that plays nice with sensitive, acne-prone skin.
In short, clascoterone delivers results—without wrecking your skin in the process.
J Drugs Dermatol. 2025;24(4):397-402. doi:10.36849/JDD.8774
