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Attenuation of Atopic Dermatitis in Newborns, Infants, and Children With Prescription Treatment and Ceramide-Containing Skin Care: A Systematic Literature Review and Consensus

By November 18, 2025No Comments

From the Vault: A popular consensus paper recommends newborn‑to‑child barrier care with ceramide‑containing moisturizers to delay flares and reduce steroid need

We pulled this widely read JDD article because it synthesizes practical consensus for clinicians who manage at‑risk infants and children. A six‑expert panel of pediatric dermatologists used a modified Delphi process to produce five statements integrating evidence and clinical experience: newborn and infant skin have distinct functional vulnerabilities, caregiver counseling on product selection is essential, and tailored prescription and skincare routines improve outcomes. Randomized and cohort data suggest that prophylactic, continuous application of lipid‑containing moisturizers begun in early infancy is more likely to delay atopic dermatitis onset and extend time to flares than to prevent disease entirely, with the magnitude of benefit greatest in high‑risk populations; benefits may wane within a year after stopping daily use. The consensus therefore stresses routine use of gentle cleansers and barrier‑lipid moisturizers (eg, ceramide‑containing) from birth onward for predisposed infants to mitigate severity and potentially attenuate the atopic march.

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