Severe Cutaneous Adverse Drug ReactionDue to Fluconazole

November 2008 | Volume 7 | Issue 11 | Case Reports | 1084 | Copyright © November 2008

Laura J. Umstattd Lester MD, Julie K. Brantley MD,Rebecca L. Kelso MD, Brent C. Kelly MD,Mathew S. Petitt DO, Michael G. Wilkerson MD

Fluconazole is a rare cause of severe cutaneous adverse drug reactions. A case of a diffuse, exfoliative eruption due to fluconazole is presented. Convincing arguments for a diagnosis of both widespread bullous fixed drug eruption and toxic epidermal necrolysis are made. The clinical presentation, diagnosis, and differentiation of these 2 severe cutaneous acute drug reactions are discussed.