INTRODUCTIONAcne vulgaris is a chronic inflammatory disease of the pilosebaceous follicle. The main factors of acne pathophysiology are hyperkeratinization of the pilosebaceous infundibulum, leading to the formation of comedones, increased…
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INTRODUCTIONDysregulation of Janus kinase (JAK) pathways from uncontrolled cytokine signaling comprises the pathological basis for many complex inflammatory disorders.1 Since JAK-family receptors are activated by numerous ligands, including several interleukins…
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INTRODUCTIONCalcific arteriolopathy (CA), also known as calciphylaxis, is a systemic vascular disorder characterized by calcium deposits in the arteriolar tunica media, tunica intima hyperplasia, and endovascular fibrosis, leading to ischemic…
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INTRODUCTIONNon-melanoma skin cancer (NMSC) is the most commonly diagnosed cancer in Canada with incidence rates continuing to rise.1-3 Basal cell carcinoma is the most common of these skin cancers, with…
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Prurigo nodularis (PN) was first accurately described more than a century ago by Hyde and Montgomery as chronic itchy nodules commonly noted in symmetric distribution on extensor sites of limbs,…
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INTRODUCTIONPatient Journey and the Burden of Systemic Comorbidities and Sequalae in Prurigo Nodularis Prurigo Nodularis (PN) is a relatively rare condition with prevalence estimates as low as 18 per 100,000…
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In this supplement:New Horizons in Our Understanding of Prurigo Nodularis and Its Management Prurigo Nodularis: Current Clinicopathologic Overview and PsychodermatologicalPerspectives Patient Journey and the Burden of Systemic Comorbidities and Sequalae…
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INTRODUCTIONPrurigo nodularis (PN) is a neurocutaneous pruritic disorder that disproportionately affects black individuals.1 Recent advances in research technologies have allowed for granular elucidation of the pathogenesis of the disease. There…
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In this supplement: Pediatric Atopic Dermatitis Patient Cases Integrating Ceramides-Containing Cleansers and Moisturizers into Prescription Treatment and Maintenance ApproachesIntroduction: Atopic dermatitis (AD) is a common, chronic recurrent disorder typically starting…
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INTRODUCTIONAtopic dermatitis (AD) is a common, chronicrecurrent disorder associated with pruritus and genetic predisposition diagnosed at a mean age of 1.6 years.1,2 The first AD flares frequently occur in infancy…
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INTRODUCTIONPrurigo nodularis (PN) is a chronic skin disease classically characterized by refractory pruritus and nodular skin lesions, although a wide spectrum of variation in both sensory symptoms and lesional appearance…
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INTRODUCTIONHalo Nevi (HN) or Sutton’s nevi, are nevomelanocytic lesions surrounded by a ring of depigmentation. HN typically occur in adolescence and may affect 1% of the population.1 Sometimes they herald…
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