Osteoinvasive Subungual Melanoma: A Case and Review

February 2010 | Volume 9 | Issue 2 | Case Reports | 159 | Copyright © February 2010

Rebecca Kleinerman MD, David Kriegel MD, Imran Amir MD, Patrick O. Emanuel MD,Bryan C. Markinson DPM

Subungual melanoma is a relatively rare variant of melanoma, accounting for 0.7–3.5% of all melanoma cases in the Caucasian population. Curiously, it occurs in 8–33% of cases in black, Asian, Native American and Hispanic populations, which generally face a substantially lower risk of melanoma. Herein the authors report the case of a 69-year-old Hispanic female with a subungual melanoma of the acral lentiginous type that directly invaded the periosteum, cortex and medulla of the distal phalanx. In addition, we review published reports of acral lentiginous melanoma with osseous invasion and discuss the evidence, on a molecular level, for this entity’s aggressive pattern of invasion. The review of cases is limited to those found through the PubMed search engine.