A Novel Moisturizer Formulated With Micronized Centella asiatica and Mandelic Acid Improves Mature, Crepey Skin

September 2026 | Volume 25 | Issue 9 | 833 | Copyright © September 2026


Published online August 31, 2026

Glynis Ablon MDa,b, Christine Emesiani PharmDc, Sindhu Garimella MSc, Matthew Meckfessel PhDc, Thu Q. Nguyen PhDc, Alan Widgerow MBBCh MMedc, Todd Schlesinger MDd

aDepartment of Dermatology, University of California, Los Angeles, CA
bAblon Skin Institute & Research Center, Manhattan Beach, CA
cGalderma Laboratories, LP, Fort Worth, TX
dClinical Research Center of the Carolinas, Charleston, SC; Department of Dermatology, The George Washington University School of Medicine and Health Sciences, Washington, DC

Abstract
Background: Dermatoporosis is a condition of fragile, aging skin that manifests as altered pH, wrinkles, laxity, easy bruising, and hyperpigmentation. This study evaluated efficacy, safety, and subject perception after the use of a novel cream, GC (Galderma Laboratories, LP, Fort Worth, TX), on subjects with mature, aging skin.
Methods: A 12-week multicenter, randomized, blinded, in-use study enrolled female and male subjects aged 40 to 60 years of all races, ethnicities, and Fitzpatrick skin types. Subjects were required to have a history of fragile skin and dry, crepey skin on the knees and thighs. GC cream was applied to knee and upper thigh skin twice daily. Assessments included clinical grading, digital photography, bioinstrumentation (skin texture, pH, and heatmap hydration), standard safety assessments, and satisfaction.
Results: Use of GC cream for 12 weeks resulted in significant improvements in skin crepiness, photodamage, and firmness, as well as decreased skin pH and early improvements in skin roughness and smoothness from baseline. Corneometer heatmapping documented improved skin hydration over baseline. No adverse events were reported; the GC cream was well tolerated, and subjects reported high satisfaction.
Conclusion: Twice-daily application of the novel GC skin cream significantly improved the overall skin quality of mature, aging skin, including crepiness, photodamage, firmness, texture, pH, and hydration. GC cream was well tolerated with high subject satisfaction. These data are intended to help guide healthcare providers and patients in choosing an effective moisturizer that was specifically designed for patients with fragile, mature skin.

INTRODUCTION

The skin naturally atrophies with age, leading to fragility, poor wound healing, and an increased risk of skin tears.1 Skin aging is characterized by multiple features, including wrinkling and rough-textured appearance; a loss of contour, elasticity, and firmness; and an increase in laxity and crepiness.1-3 In addition, changes in skin pH to a more basic pH may have negative consequences for the acid mantle, skin microbiome, and skin barrier, while correcting the elevation may improve overall skin function.4,5 In older patients, xerosis (dry, scaly skin) can impair skin barrier function and has been associated with a higher incidence of pressure injuries.6

Dermatoporosis is a chronic condition of fragile, aging skin manifested by skin atrophy, senile purpura, and pseudoscars.7-9 The pathophysiology of this condition is not fully understood.10 Dermatoporosis is most commonly found on sun-exposed areas of skin.7,11 Early clinical manifestations of dermatoporosis have been reported as early as 40 to 60 years, although prevalence in this younger age group is not well characterized. Prevalence ranges from 27.0% to 37.5% in patients aged 60 years and older.12-14 While advanced age is the most prominent risk factor, other risk factors include chronic actinic damage, genetic susceptibility, long-term use of topical and systemic corticosteroids, chronic kidney disease, anticoagulant use, chronic obstructive pulmonary disease, epidermal growth factor receptor use, and lack of exercise.11 In later stages, dermatoporosis can result in frequent skin tears, delayed wound healing, nonhealing atrophic ulcers, and dissecting hematomas.7-9

A healthy skin barrier protects against dehydration, microorganisms, allergens, irritants, reactive oxygen species, and ultraviolet radiation.15,16 Consistent skincare regimens