Latin America Cutaneous Oncology Management (LACOM) II: A Practical Algorithm for Managing Skin Toxicities in Oncology Patients
July 2026 | Volume 25 | Issue 7 | 621 | Copyright © July 2026
Published online June 30, 2026
Daniel Alcalá Pérez MDa, Anneke Andriessen PhDb, Vanja Adzovic PharmDc, Sebastian Andreani MDd, Herbert Cárdenas MDe, Marcela Moreno MDf, Daniel Motola Kuba MDg, Julia Riganti MDh, José Enrique Ollague MDi, Alejandra Toquica MDj, Mario Lacouture MD FAADk
aMexican Society of Dermatology, Centro Dermatológico Dr. Ladislao de la Pascua, México City, Mexico
bRadboud UMC, Andriessen Consultants, Malden, The Netherlands
cBlue Quill Communications, Toronto, Canada
dDermatology Department, Universidad del Desarrollo, Facultad de Medicina Clínica Alemana, Santiago, Región Metropolitana, Chile
eInstituto Nacional de Enfermedades Neoplásicas, Perú
fOncodermatologia Instituto Oncologico Alexander Fleming, University of Buenos Aires, Argentina
gMedica Sur Hospital, Oncology Center, Mexico City, Mexico
hDepartment of Dermatology, Hospital Italiano de Buenos Aires, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina
iHospital General Guasmo Sur, Ministry of Health, Guayaquil, Ecuador
jOncodermatology Department. Hospital Universitario San Ignacio. Fundacion CTIC. Bogotá, Colombia
kOnco-Dermatology Program NYU- Langone, New York City, NY, USA
Abstract
Background: Anticancer treatments are associated with cutaneous adverse events (cAEs) that can severely impact patients' quality of life (QoL) and interfere with treatment outcomes. LACOM aims to support clinicians in preventing and managing cAEs to optimize patient outcomes.
Methods: A panel of dermatologists, clinical oncologists, and radiation oncologists developed an evidence-based algorithm for the prevention and treatment of cancer treatment-related cAEs using a skincare regimen that includes hygiene, moisturization, sun protection, and camouflage products.
Results: The LACOM II algorithm discusses patient education before cancer treatment, appropriate skincare, triage, and the importance of treating emerging cAEs with a multidisciplinary team.
Conclusions: Integrating proactive education, safe and effective skincare, triage, and reaction-specific management of cAEs is essential to optimize the care of patients living with cancer. The LACOM II algorithm provides evidence- and opinion-based best-practice recommendations to support clinicians working with oncology patients throughout the continuum of care, achieving optimal outcomes and improving patients' QoL.
INTRODUCTION
According to the GLOBOCAN Estimates of Incidence and Mortality Worldwide, approximately 1.5 million new cancer cases and 749,000 cancer deaths were estimated to occur in Latin America and the Caribbean in 2022. The age-standardized incidence rate was 199.9 for males, 177.4 for females, and 186.0 for both sexes.1 The top three leading cancers for men in this region were prostate cancer, colorectal cancer, and lung cancer, while the three leading cancers for women were breast cancer, colorectal cancer, and cervical cancer.1
While breast cancer is the leading cause of cancer death among women in most Latin American countries, cervical cancer is the leading cause of cancer death among women in Belize, Honduras, and El Salvador in Central America and in Bolivia and Peru in South America. In males, prostate cancer is the leading cause of cancer death in most countries in this region, while lung cancer is the most frequent cause of cancer death in Argentina, Bolivia, Brazil, Cuba, and Uruguay.2
Several treatment options are available depending on the type and stage of cancer and patient-related factors. These options
