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Implementing Psoriatic Arthritis Screening and Dietary Interventions in Dermatology Practice: A Prospective Clinical Study

November 2026 | Volume 25 | Issue 11 | 1033 | Copyright © November 2026


Published online October 30, 2026

Victor Czerkasij DNPa, Sarah Romanelli MDb, Beth Childs MDc, Richard Rookwood MDb, Kathy Lenz DNPa, Wilaiporn Rojjanasrirat PhDa, Alice B. Gottlieb MD PhDc

aGraceland University, Independence, MO
bAlbert Einstein College of Medicine, The Bronx, NY
cDepartment of Dermatology, UT Southwestern Medical Center, Dallas, TX

Abstract
Background: Psoriatic arthritis (PsA) is a common, underdiagnosed inflammatory comorbidity of psoriasis (PsO) that can lead to irreversible joint damage without early intervention. Dermatologists are uniquely positioned to facilitate early PsA detection; however, routine screening remains inconsistent. Lifestyle interventions such as the Mediterranean diet (MD) may further enhance treatment outcomes when combined with biologic therapy.
Methods: This prospective, single-center, non-randomized controlled study evaluated routine PsA screening and treatment outcomes in an outpatient dermatology clinic. Adults with dermatologist-confirmed PsO were screened for PsA using the Psoriasis Epidemiology Screening Tool (PEST). Patients screening positive self-selected into biologic therapy alone or biologic therapy plus MD intervention. Pain severity was assessed at baseline and 1 month; logistic regression identified predictors of PsA screening positivity, and one-way ANOVA compared pain score changes among treatment groups.
Results: a total of 117 PsO patients were screened for PsA; 72 (61.5%) screened positive, representing a statistically significant increase compared with PsA detection prior to implementation of routine PEST screening (P<0.001).Pain severity was the only significant predictor of a positive PsA screen (P<0.001). Both guselkumab- and secukinumab-treated patients were evaluated with and without adherence to the MD; guselkumab combined with the MD demonstrated the greatest reduction in pain scores at 1 month compared with biologic therapy alone (mean change 3.13 ± 1.12; P=0.01).
Conclusions: Implementation of routine PsA screening in dermatology practice markedly increased PsA detection. Combining biologic therapy with dietary intervention was associated with greater short-term pain reduction, supporting the utility of lifestyle changes and counseling alongside pharmacologic management in PsA care.

 

INTRODUCTION

Psoriatic arthritis (PsA) is a chronic, immune-mediated inflammatory disease that affects up to 30% of patients with psoriasis (PsO), corresponding to nearly 3 million individuals in the United States.1,2 The annual incidence is estimated at 6 per 100,000 people, with a prevalence of 1 to 2 per 1,000, affecting men and women equally.3 PsO is associated with a significant comorbidity burden, including increased risk of PsA, cardiovascular disease, inflammatory bowel disease, and psychological disorders, among others.4 Patients frequently report impaired quality of life due to pain, fatigue, depression, social impairment, and disability, and up to 20% progress to irreversible joint damage and severe functional limitations without timely treatment.5

Dermatologists managing PsO are in a unique position to facilitate early PsA detection; however, screening strategies and implementation remain inconsistent. Studies show that up to 40% of dermatology providers do not routinely screen PsO patients for PsA, leading to delayed diagnosis and missed opportunities for early intervention.6,7 Barriers include limited time during patient visits, lack of training in screening tools, and uncertainty regarding next steps or treatment modifications once PsA is suspected.8,9 Validated, low-cost instruments such as the Psoriasis Epidemiological Screening Tool (PEST) offer an efficient means of identifying patients at risk,10 yet are underutilized.