Generalized Eruptive Keratoacanthomas of GrzybowskiTreated with Isotretinoin

November 2008 | Volume 7 | Issue 11 | Case Reports | 1069 | Copyright © November 2008

Travis Vandergriff MD, Krystal Nakamura MD, Whitney A. High MD

Generalized eruptive keratoacanthomas of Grzybowski is a rare condition of unknown etiology. The disease is characterized by the abrupt onset of many small crateriform papules on the skin and mucous membranes. The authors report of a man with multiple eruptive keratoacanthomas of Grzybowski who responded favorably to oral isotretinoin therapy. After 2 years of follow-up, a complete regression of all lesions was observed, and this rapid clearance under isotretinoin therapy is intriguing with regard to the possible etiology of the condition.