FULL SUPPLEMENT: Real-World Split-Face Case Series of a Phyto Polydeoxyribonucleotide (PDRN) Serum in Integrative Skincare

Inflammation and photodamage are largely considered the leading contributors to premature skin aging as they lead to decreased collagen content in the skin. Collagen, the most abundant protein in the extracellular matrix (ECM) of skin, has been shown to decrease in abundance by approximately 1-1.5% per year, leading to skin aging. Polydeoxyribonucleotides (PDRN) and polyribonucleotides (PN) are small and medium deoxyribonucleotide (DNA) or ribonucleotide (RNA) chains have been shown to boost collagen production and skin regeneration.