FULL SUPPLEMENT: Ammonium Lactate for Xerotic Skin Conditions: Biomimetic Effects and Clinical Relevance

Xerosis is a common and clinically significant dermatologic concern, affecting patients across a broad spectrum of conditions, including atopic dermatitis, psoriasis, ichthyosis, and age- or environment-related dry skin. In addition to visible scaling and roughness, xerosis is frequently associated with pruritus and discomfort, and may negatively impact quality of life and treatment adherence when persistent or inadequately controlled. At a physiological level, xerosis reflects disruption of stratum corneum structure and function, including reduced water content, impaired corneocyte desquamation, and barrier dysfunction, processes that are closely linked to depletion of natural moisturizing factors (NMFs) and alterations in skin surface pH.