Fluconazole-associated Stevens-Johnson Syndrome

October 2010 | Volume 9 | Issue 10 | Case Reports | 1272 | Copyright © October 2010

Jayantha Thiyanaratnam BS, Philip R. Cohen MD, Shanti Powell MD

Fluconazole uncommonly causes Stevens-Johnson syndrome. A young Indian man who developed this adverse effect after his second dose of fluconazole is described. The characteristics of previously reported individuals with fluconazole-associated Stevens-Johnson syndrome and toxic epidermal necrolysis are also summarized: three out of five of the patients were immunocompromised, five out of five were hospitalized, and all had complete resolution of this drug-induced condition.