Minocycline-Induced Immune Thrombocytopenia presenting as Schamberg’s Disease Schamberg Disease

Minocycline hydrochloride, a synthetic tetracycline, is a systemic antibiotic that has received much attention over the past several years. Currently, minocycline is considered the most widely prescribed oral antibiotic in the management of acne¹. Minocycline has been associated with autoimmune events², hepatitis³, lupus-like syndromes⁴, serum sickness, vasculitis, Sweet's syndrome⁵, and hyperpigmentation^6,7 . We report a case of a patient who developed drug-induced immune thrombocytopenic purpura (DITP) after taking minocycline. The initial clinical presentation of nonpalpable, discrete nonblanching petechiae and cayenne pepper-like macules on his lower legs was diagnosed as pigmented purpuric dermatosis (Schamberg's disease Schamberg disease). We report the first case of drug-induced immune thrombocytopenic purpura  DITP with the clinical picture of Schamberg's disease (schamberg disease) associated with minocycline therapy.